Ribozymes targeted to apo(a) mRNA

ABSTRACT

Enzymatic RNA molecules which cleave apo(a) mRNA.

FIELD OF THE INVENTION

The present invention relates to therapeutic compositions and methods for the treatment or diagnosis of diseases or conditions related to Lp(a) levels, such as atherosclerosis, myocardial infarction, stroke, and restenosis.

BACKGROUND OF THE INVENTION

The following is a brief description of the physiological role of Lp(a). The discussion is not meant to be complete and is provided only for understanding of the invention that follows. This summary is not an admission that any of the work described below is prior art to the claimed invention.

Low density lipoproteins (LDLs) are mainly composed of cholesterol, phospholipids and a single hydrophobic protein, apolipoprotein B [apoB]. They are considered as the major carriers of cholesterol in human plasma (for review see Uterman, G. (1989) Science 246, 904-910). ApoB, the only protein subunit of LDL, recognizes and binds to LDL receptors on the surface of cells. This LDL-LDL receptor interaction results in the internalization of the LDL and the eventual release of cholesterol inside the cell.

A modified form of LDL, termed as lipoprotein (a) [Lp(a)], was discovered in 1963 [Berg, K. (1963) Acta Pathol. Microbiol. Scand. 59, 369]. Covalent linkage of an additional glycoprotein, apo(a), to the LDL distinguishes Lp(a) from LDL. Several studies have recently suggested that elevated levels of Lp(a) in human plasma is linked to heart disease (Gurakar, et al., (1985) Atherosclerosis 57, 293-301; Leren, et al., (1988) Atherosclerosis 73, 135-141; Utermann, Supra). The Lp(a) levels range over 1000 fold and individuals with top quartile of plasma Lp(a) levels have two-to five-fold increased probability of developing atherosclerosis.

Atherosclerosis is a disease associated with hardening and loss of elasticity of arterial walls. High concentrations of cholesterol, in the form of Lp(a), in human blood plasma is one of the most important factors responsible for atherosclerosis. Deposition of cholesterol in the Macrophages and smooth muscle cells associated with arterial walls cause plaques (atheromatous lesions) which cause proliferation of adjoining smooth muscle cells. With time, these plaques grow in size causing hardening of the arterial walls and loss of elasticity, which in turn results in rupturing of the arterial walls, blood clotting and blockage of blood flow in the artery (for datails see Textbook of medical physiology Guyton, A. C., (Saunders Company, Philadelphia, 1991) pp. 761-764).

Lp(a) and/or apo(a) levels correlate well with an increased risk of atherosclerosis and its subsequent manifestations such as myocardial infarction, stroke, and restenosis. The apo(a) protein is unique to humans, Old World primates and hedgehogs; its absence in common laboratory animals has made exploration of the physiological role of apo(a) levels difficult. Recently, a transgenic mouse expressing the human gene encoding apo(a) was constructed [Lawn et al., (1992) Nature 360, 670-672]. The transgenic mice are more susceptible than control liter-mates to the development of lipid-rich regions in the aorta. Moreover, human apo(a) expression colocalizes to the regions of fat deposition. Thus, overexpression of apo(a) directly leads to atherosclerotic-like lesions in experimental animals. This observation lends credence to the hypothesis that elevated levels of apo(a) in humans contribute to atherosclerotic disease.

Apolipoprotein(a) is a large glycoprotein which varies in size from 300-800 KDa. Thirty four different isoforms have been characterized from human plasma. The only human cDNA clone currently available encompass 14 kilobase message that encodes apo(a) [McLean et al., (1987) Nature 330, 132-137]. A Rhesus monkey cDNA representing a part of the 3' end of the apo(a) mRNA has also been cloned and sequenced (Tomlinson et al., 1989 J. Biol., Chem. 264, 5957-5965). Sequence analysis of the cloned cDNA revealed two unique facets of the apo(a) structure. First, the apo(a) cDNA is remarkably repetitious. The reconstructed apo(a) cDNA encodes a protein of 4,529 amino acids; 4,210 of the residues are present in 37 repeats of 114 amino acids each. The repeated units themselves are especially homologous; 24 are identical in nucleotide sequence, four more share a sequence that differs in only three nucleotides and the remaining repeats differ by only 11 to 71 bases.

Secondly, apolipoprotein(a) is highly homologous to the serine protease, plasminogen. Plasminogen consists of five repeated homologous domains termed kringles (which are approximately 50% homologous in their amino sequences) followed by a trypsin-like protease domain. Kringle IV of plasminogen is very homologous to the 37 repeats of apo(a) [75-85% at the protein level). In addition, the 5' untranslated region, the signal peptide region, kringle V, the protease domain, and the 3' untranslated region of plasminogen are 98%, 100%, 91%, 94% and 87% homologous to apo(a) sequences, respectively. Relative to plasminogen, apo(a) is missing kringles I, II, and III and, as mentioned above, has extensively duplicated kringle IV. Despite the high degree of homology apo(a) cannot be converted into a protease by tissue type plasminogen activator (tPA). This is because of a single amino acid substitution in apo(a) at the site of activation of plasminogen by tPA (Utermann, supra). IN vitro studies have indicated that apo(a) and Lp(a) compete with plasminogen for binding to the plasminogen receptor and fibrin which supports the correlation between high Lp(a) levels and myocardial infraction (Gonzalez-Gronow et al., (1989) Biochemistry 28, 2374-2378; Hajjar et al., (1989) Nature 339, 303-305; Miles et al., (1989) Nature 339, 301-303). Recent in vivo studies in human (Moliterno et al., 1993 Circulation 88, 935-940) and monkey (Williams et al., 1993 Atheroscler. Thromb. 13, 548-554) support a role for Lp(a) in preventing clot lysis.

The extraordinary homology between apo(a) and plasminogen presents several barriers to drug development. Small molecule inhibitors of apo(a) would have to selectively bind apo(a) without negatively impacting plasminogen function. Similarly, antisense approaches will be limited by the overall nucleotide sequence homology between the two genes. Current dietary and drug therapies (Gurakar, et al., supra; Leren et al., supra), with the exception of nicotinic acid, have little or no effect on apo(a) levels.

Applicant now shows that these same limitations are opportunities for ribozyme therapy. The cleavage site specificity of ribozymes allows one to identify ribozyme target sites present in apo(a) mRNA but completely absent in the mRNA of plasminogen. For instance, there are 13 hammerhead cleavage sites present in the highly conserved kringles of apo(a) that are not present in kringle IV of plasminogen. Likewise, the last kringle repeat, protease domain and 3' untranslated region of apo(a) contain 21 hammerhead ribozyme cleavage sites present in apo(a) that are not present in plasminogen. Thus, ribozymes that target apo(a) mRNA represent unique therapeutics and diagnostic tools for the treatment and diagnosis of those at high risk of atherosclerosis.

SUMMARY OF THE INVENTION

This invention relates to ribozymes, or enzymatic RNA molecules, directed to cleave mRNA species encoding apo(a). In particular, applicant describes the selection and function of ribozymes capable of cleaving this RNA and their use to reduce levels of apo(a) in various tissues to treat the diseases discussed herein. Such ribozymes are also useful for diagnostic uses.

Ribozymes that cleave apo(a) mRNA represent a novel therapeutic approach to atherosclerosis. Ribozymes may show greater perdurance or lower effective doses than antisense molecules due to their catalytic properties and their inherent secondary and tertiary structures. Such ribozymes, with their catalytic activity and increased site specificity (as described below), represent more potent and safe therapeutic molecules than antisense oligonucleotides.

Applicant indicates that these ribozymes are able to inhibit expression of apo(a) and that the catalytic activity of the ribozymes is required for their inhibitory effect. Those of ordinary skill in the art, will find that it is clear from the examples described that other ribozymes that cleave target apo(a) encoding mRNAs may be readily designed and are within the invention.

Six basic varieties of naturally-occurring enzymatic RNAs are known presently. Each can catalyze the hydrolysis of RNA phosphodiester bonds in trans (and thus can cleave other RNA molecules) under physiological conditions. Table I summarizes some of the characteristics of these ribozymes. In general, enzymatic nucleic acids act by first binding to a target RNA. Such binding occurs through the target binding portion of a enzymatic nucleic acid which is held in close proximity to an enzymatic portion of the molecule that acts to cleave the target RNA. Thus, the enzymatic nucleic acid first recognizes and then binds a target RNA through complementary base-pairing, and once bound to the correct site, acts enzymatically to cut the target RNA. Strategic cleavage of such a target RNA will destroy its ability to direct synthesis of an encoded protein. After an enzymatic nucleic acid has bound and cleaved its RNA target, it is released from that RNA to search for another target and can repeatedly bind and cleave new targets.

The enzymatic nature of a ribozyme is advantageous over other technologies, such as antisense technology (where a nucleic acid molecule simply binds to a nucleic acid target to block its processing and translation) since the concentration of ribozyme necessary to affect a therapeutic treatment is lower than that of an antisense oligonucleotide. This advantage reflects the ability of the ribozyme to act enzymatically. Thus, a single ribozyme molecule is able to cleave many molecules of target RNA. In addition, the ribozyme is a highly specific inhibitor, with the specificity of inhibition depending not only on the base pairing mechanism of binding to the target RNA, but also on the mechanism of target RNA cleavage. Single mismatches, or base-substitutions, near the site of cleavage can completely eliminate catalytic activity of a ribozyme. Similar mismatches in antisense molecules do not prevent their action (Woolf, T. M., et al., 1992, Proc. Natl. Acad. Sci. USA, 89, 7305-7309). Thus, the specificity of action of a ribozyme is greater than that of an antisense oligonucleotide binding the same RNA site.

In preferred embodiments of this invention, the enzymatic nucleic acid molecule is formed in a hammerhead or hairpin motif, but may also be formed in the motif of a hepatitis delta virus, group 1 intron or RNaseP RNA (in association with an RNA guide sequence) or Neurospora VS RNA. Examples of such hammerhead motifs are described by Rossi et al., 1992, Aids Research and Human Retroviruses, 8, 183, of hairpin motifs by Hampel et al., "RNA Catalyst for Cleaving Specific RNA Sequences," filed Sep. 20, 1989, which is a continuation-in-part of U.S. Ser. No. 07/247,100 filed Sep. 20, 1988, Hampel and Tritz, 1989, Biochemistry, 28, 4929, and Hampel et al., 1990, Nucleic Acids Res. 18,299, and an example of the hepatitis delta virus motif is described by Perrotta and Been, 1992, Biochemistry, 31, 16, of the RNaseP motif by Guerrier-Takada et al., 1983, Cell, 35, 849, Neurospora VS RNA ribozyme motif is described by Collins (Saville and Collins, 1990 Cell 61, 685-696; Saville and Collins, 1991 Proc. Natl. Acad. Sci. USA 88, 8826-8830; Collins and Olive, 1993 Biochemistry 32, 2795-2799) and of the Group I intron by Cech et al., U.S. Pat. No. 4,987,071. These specific motifs are not limiting in the invention and those skilled in the art will recognize that all that is important in an enzymatic nucleic acid molecule of this invention is that it has a specific substrate binding site which is complementary to one or more of the target gene RNA regions, and that it have nucleotide sequences within or surrounding that substrate binding site which impart an RNA cleaving activity to the molecule.

The invention provides a method for producing a class of enzymatic cleaving agents which exhibit a high degree of specificity for the RNA of a desired target. The enzymatic nucleic acid molecule is preferably targeted to a highly conserved sequence region of a target apo(a) encoding mRNA such that specific treatment of a disease or condition can be provided with either one or several enzymatic nucleic acids. Such enzymatic nucleic acid molecules can be delivered exogenously to specific cells as required. Alternatively, the ribozymes can be expressed from DNA vectors that are delivered to specific cells.

Synthesis of nucleic acids greater than 100 nucleotides in length is difficult using automated methods, and the therapeutic cost of such molecules is prohibitive. In this invention, small enzymatic nucleic acid motifs (e.g., of the hammerhead or the hairpin structure) are used for exogenous delivery. The simple structure of these molecules increases the ability of the enzymatic nucleic acid to invade targeted regions of the mRNA structure. However, these catalytic RNA molecules can also be expressed within cells from eukaryotic promoters (e.g., Scanlon, K. J., et al., 1991, Proc. Natl. Acad. Sci. USA, 88, 10591-5; Kashani-Sabet, M., et al., 1992, Antisense Res. Dev., 2, 3-15; Dropulic, B., et al., 1992, J Virol, 66, 1432-41; Weerasinghe, M., et al., 1991, J Virol, 65, 5531-4; Ojwang, J. O., et al., 1992, Proc. Natl. Acad. Sci. USA, 89, 10802-6; Chen, C. J., et al., 1992, Nucleic Acids Res., 20, 4581-9; Sarver, H., et al., 1990, Science, 247, 1222-1225)). Those skilled in the art realize that any ribozyme can be expressed in eukaryotic cells from the appropriate DNA vector. The activity of such ribozymes can be augmented by their release from the primary transcript by a second ribozyme (Draper et al., PCT WO93/23569, and Sullivan et al., PCT WO94/02595, both hereby incorporated in their totality by reference herein; Ohkawa, J., et al., 1992, Nucleic Acids Symp. Ser., 27, 15-6; Taira, K., et al., 1991, Nucleic Acids Res., 19, 5125-30; Ventura, M., et al., 1993, Nucleic Acids Res., 21, 3249-55).

Thus, in a first aspect, the invention features ribozymes that inhibit apo(a) production. These chemically or enzymatically synthesized RNA molecules contain substrate binding domains that bind to accessible regions of their target mRNAs. The RNA molecules also contain domains that catalyze the cleavage of RNA. The RNA molecules are preferably ribozymes of the hammerhead or hairpin motif. Upon binding, the ribozymes cleave the target apo(a) encoding mRNAs, preventing translation and protein accumulation. In the absence of the expression of the target gene, a therapeutic effect may be observed.

By "inhibit" is meant that the activity or level of apo(a) encoding mRNA is reduced below that observed in the absense of the ribozyme, and preferably is below that level observed in the presence of an inactive RNA molecule able to bind to the same site on the mRNA, but unable to cleave that RNA.

Such ribozymes are useful for the prevention of the diseases and conditions discussed above, and any other diseases or conditions that are related to the level of apo(a) activity in a cell or tissue. By "related" is meant that the inhibition of apo(a) mRNA translation, and thus reduction in the level of apo(a), will relieve to some extent the symptoms of the disease or condition.

Ribozymes are added directly, or can be complexed with cationic lipids, packaged within liposomes, or otherwise delivered to target cells. The RNA or RNA complexes can be locally administered to relevant tissues through the use of a catheter, infusion pump or stent, with or without their incorporation in biopolymers. In preferred embodiments, the ribozymes have binding arms which are complementary to the sequences in Tables II, IV, VI and VII. Examples of such ribozymes are shown in Tables III, V, VI and VII Examples of such ribozymes consist essentially of sequences defined in these Tables. By "consists essentially of" is meant that the active ribozyme contains an enzymatic center equivalent to those in the examples, and binding arms able to bind mRNA such that cleavage at the target site occurs. Other sequences may be present which do not interfere with such cleavage.

In another aspect of the invention, ribozymes that cleave target molecules and inhibit apo(a) activity are expressed from transcription units inserted into DNA, RNA, or viral vectors. Preferably, the recombinant vectors capable of expressing the ribozymes are locally delivered as described above, and transiently persist in target cells. Once expressed, the ribozymes cleave the target mRNA. The recombinant vectors are preferably DNA plasmids or adenovirus vectors. However, other mammalian cell vectors that direct the expression of RNA may be used for this purpose.

Other features and advantages of the invention will be apparent from the following description of the preferred embodiments thereof, and from the claims.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

The drawings will first briefly be described.

Drawings:

FIG. 1 is a diagrammatic representation of the hammerhead ribozyme domain known in the art. Stem II can be ≧2 base-pair long or may be a loop region without base pairing.

FIG. 2a is a diagrammatic representation of the hammerhead ribozyme domain known in the art; FIG. 2b is a diagrammatic representation of the hammerhead ribozyme as divided by Uhlenbeck (1987, Nature, 327, 596-600) into a substrate and enzyme portion; FIG. 2c is a similar diagram showing the hammerhead divided by Haseloff and Gerlach (1988, Nature, 334, 585-591) into two portions; and FIG. 2d is a similar diagram showing the hammerhead divided by Jeffries and Symons (1989, Nucl. Acids. Res., 17, 1371-1371) into two portions.

FIG. 3 is a representation of the general structure of the hairpin ribozyme domain known in the art. H, is A, U or C. Y is U or C. N is A, U, G, or C. N' is the complementary sequence of N. Helix 4 can be ≧2 base-pair long.

FIG. 4 is a representation of the general structure of the hepatitis delta virus ribozyme domain known in the art.

FIG. 5 is a representation of the general structure of the Neurospora VS RNA enzyme motif.

FIG. 6 is a schematic representation of an RNase H accessibility assay. Specifically, the left side of FIG. 6 is a diagram of complementary DNA oligonucleotides bound to accessible sites on the target RNA. Complementary DNA oligonucleotides are represented by broad lines labeled A, B, and C. Target RNA is represented by the thin, twisted line. The right side of FIG. 5 is a schematic of a gel separation of uncut target RNA from a cleaved target RNA. Detection of target RNA is by autoradiography of body-labeled, T7 transcript. The bands common to each lane represent uncleaved target RNA; the bands unique to each lane represent the cleaved products.

RIBOZYMES

Ribozymes of this invention block to some extent apo(a) expression and can be used to treat disease or diagnose such disease. Ribozymes will be delivered to cells in culture and to tissues in animal models of Lp(a). Ribozyme cleavage of apo(a) mRNA in these systems may prevent or alleviate disease symptoms or conditions.

Target sites

Targets for useful ribozymes can be determined as disclosed in Draper et al supra. Sullivan et al., supra, as well as by Draper et al., "Method and reagent for treatment of arthritic conditions U.S. Ser. No. 08/152,487, filed Nov. 12, 1993, and hereby incorporated by reference herein in totality. Rather than repeat the guidance provided in those documents here, below are provided specific examples of such methods, not limiting to those in the art. Ribozymes to such targets are designed as described in those applications and synthesized to be tested in vitro and in vivo, as also described. Such ribozymes can also be optimized and delivered as described therein. While specific examples to monkey and human RNA are provided, those in the art will recognize that the equivalent human RNA targets described can be used as described below. Thus, the same target may be used, but binding arms suitable for targetting human RNA sequences are present in the ribozyme. Such targets may also be selected as described below.

The sequence of human and monkey apo(a) mRNA can be screened for accessible sites using a computer folding algorithm. Regions of the mRNA that did not form secondary folding structures and that contain potential hammerhead or hairpin ribozyme cleavage sites can be identified. These sites are shown in Tables II, IV, and VI-VII. (All sequences are 5' to 3' in the tables.) While monkey and human sequences can be screened and ribozymes thereafter designed, the human targetted sequences are of most utility. However, as discussed in Stinchcomb et al. "Method and Composition for Treatment of Restenosis and Cancer Using Ribozymes," U.S. Ser. No. 08/245,466, filed May 18, 1994, and hereby incorporated by reference herein, monkey targeted ribozmes are useful to test efficacy of action of the ribozyme prior to testing in humans. The nucleotide base position is noted in the Tables as that site to be cleaved by the designated type of ribozyme.

Ribozyme target sites were chosen such that the cleavage sites are present in apo(a) mRNA but completely absent in the mRNA of plasminogen (Tables II, IV, VI and VII). This is because there exists extraordinary homology between apo(a) and plasminogen (see above).

It must be established that the sites predicted by the computer-based RNA folding algorithm correspond to potential cleavage sites. Hammerhead and hairpin ribozymes are designed that could bind and are individually analyzed by computer folding (Jaeger et al., 1989 Proc. Natl. Acad. Sci. USA, 86, 7706-7710) to assess whether the ribozyme sequences fold into the appropriate secondary structure. Those ribozymes with unfavorable intramolecular interactions between the binding arms and the catalytic core are eliminated from consideration. Varying binding arm lengths can be chosen to optimize activity. Generally, at least 5 bases on each arm are able to bind to, or otherwise interact with, the target RNA.

Referring to FIG. 6, mRNA is screened for accessible cleavage sites by the method described generally in McSwiggen, U.S. patent application Ser. No. 07/883,849 filed May 1, 1992, entitled "Assay for ribozyme target site," hereby incorporated by reference herein. Briefly, DNA oligonucleotides representing potential hammerhead or hairpin ribozyme cleavage sites are synthesized. A polymerase chain reaction is used to generate a substrate for T7 RNA polymerase transcription from human or monkey apo(a) cDNA clones. Labeled RNA transcripts are synthesized in vitro from the two templates. The oligonucleotides and the labeled transcripts are annealed, RNaseH is added and the mixtures are incubated for the designated times at 37° C. Reactions are stopped and RNA separated on sequencing polyacrylamide gels. The percentage of the substrate cleaved is determined by autoradiographic quantitation using a phosphor imaging system. From these data, hammerhead or hairpin ribozyme sites are chosen as the most accessible.

Ribozymes of the hammerhead or hairpin motif are designed to anneal to various sites in the mRNA message. The binding arms are complementary to the target site sequences described above. The ribozymes are chemically synthesized. The method of synthesis used follows the procedure for normal RNA synthesis as described in Usman et al., 1987 J. Am. Chem. Soc., 109, 7845-7854 and in Scaringe et al., 1990 Nucleic Acids Res., 18, 5433-5441 and makes use of common nucleic acid protecting and coupling groups, such as dimethoxytrityl at the 5'-end, and phosphoramidites at the 3'-end. The average stepwise coupling yields were >98%. Inactive ribozymes are synthesized by substituting a U for G₅ and a U for A₁₄ (numbering from Hertel et al., 1992 Nucleic Acids Res., 20, 3252). Hairpin ribozymes are synthesized in two parts and annealed to reconstruct the active ribozyme (Chowrira and Burke, 1992 Nucleic Acids Res., 20, 2835-2840). All ribozymes are modified to enhance stability by modification of five ribonucleotides at both the 5' and 3' ends with 2'-O-methyl groups. Ribozymes are purified by gel electrophoresis using general methods or are purified by high pressure liquid chromatography (HPLC; See Usman et al., Synthesis, deprotection, analysis and purification of RNA and ribozymes, filed May, 18, 1994, U.S. Ser. No. 08/245,736, the totality of which is hereby incorporated herein by reference.) and were resuspended in water.

The sequences of the chemically synthesized ribozymes useful in this study are shown in Tables III, V, VI, and VII. Those in the art will recognize that these sequences are representative only of many more such sequences where the enzymatic portion of the ribozyme (all but the binding arms) is altered to affect activity. For example, stem loop II sequence of hammerhead ribozymes listed in Tables III and V (5'-GGCCGAAAGGCC-3') can be altered (substitution, deletion and/or insertion) to contain any sequence provided a minimum of two base-paired stem structure can form. Similarly, stem-loop IV sequence of hairpin ribozymes listed in Tables VI and VII (5'-CACGUUGUG-3') can be altered (substitution, deletion and/or insertion) to contain any sequence provided, a minimum of two base-paired stem structure can form. The sequences listed in Tables III, V-VII may be formed of ribonucleotides or other nucleotides or non-nucleotides. Such ribozymes are equivalent to the ribozymes described specifically in the Tables.

Optimizing Ribozyme Activity

Ribozyme activity can be optimized as described by Stinchcomb et al., supra. The details will not be repeated here, but include altering the length of the ribozyme binding arms (stems I and Ill, see FIG. 2c), or chemically synthesizing ribozymes with modifications that prevent their degradation by serum ribonucleases (see e.g., Eckstein et al., International Publication No. WO 92/07065; Perrault et al., 1990 Nature 344, 565; Pieken et al., 1991 Science 253, 314; Usman and Cedergren, 1992 Trends in Biochem. Sci. 17, 334; Usman et al., International Publication No. WO 93/15187; and Rossi et al., International Publication No. WO 91/03162, as well as Usman, N. et al. U.S. patent application Ser. No. 07/829,729, and Sproat, European Patent Application 92110298.4 and U.S. Pat. No. 5,334,711 and Jennings et al., WO 94/13688, which describe various chemical modifications that can be made to the sugar moieties of enzymatic RNA molecules. All these publications are hereby incorporated by reference herein.), modifications which enhance their efficacy in cells, and removal of stem II bases to shorten RNA synthesis times and reduce chemical requirements.

Sullivan, et al., supra, describes the general methods for delivery of enzymatic RNA molecules. Ribozymes may be administered to cells by a variety of methods known to those familiar to the art, including, but not restricted to, encapsulation in liposomes, by iontophoresis, or by incorporation into other vehicles, such as hydrogels, cyclodextrins, biodegradable nanocapsules, and bioadhesive microspheres. The RNA/vehicle combination is locally delivered by direct injection or by use of a catheter, infusion pump or stent. Alternative routes of delivery include, but are not limited to, intravenous injection, intramuscular injection, subcutaneous injection, aerosol inhalation, oral (tablet or pill form), topical, systemic, ocular, intraperitoneal and/or intrathecal delivery. More detailed descriptions of ribozyme delivery and administration are provided in Sullivan, et al., supra and Draper, et al., supra which have been incorporated by reference herein.

Another means of accumulating high concentrations of a ribozyme(s) within cells is to incorporate the ribozyme-encoding sequences into a DNA expression vector. Transcription of the ribozyme sequences are driven from a promoter for eukaryotic RNA polymerase I (pol I), RNA polymerase II (pol II), or RNA polymerase III (pol III). Transcripts from pol II or pol III promoters will be expressed at high levels in all cells; the levels of a given pol II promoter in a given cell type will depend on the nature of the gene regulatory sequences (enhancers, silencers, etc.) present nearby. Prokaryotic RNA polymerase promoters are also used, providing that the prokaryotic RNA polymerase enzyme is expressed in the appropriate cells (Elroy-Stein and Moss, 1990 Proc. Natl, Acad. Sci. U.S.A., 87, 6743-7; Gao and Huang 1993 Nucleic Acids Res., 21, 2867-72; Lieber et al., 1993 Methods Enzymol., 217, 47-66; Zhou et al., 1990 Mol. Cell. Biol., 10, 4529-37). Several investigators have demonstrated that ribozymes expressed from such promoters can function in mammalian cells (e.g. Kashani-Sabet et al., 1992 Antisense Res. Dev., 2, 3-15; Ojwang et al., 1992 Proc. Natl. Acad. Sci. U.S.A., 89, 10802-6; Chen et al., 1992 Nucleic Acids Res., 20, 4581-9; Yu et al., 1993 Proc. Natl. Acad. Sci. U.S.A., 90, 6340-4; L'Huillier et al., 1992 EMBO J. 11, 4411-8; Lisziewicz et al., 1993 Proc. Natl. Acad. Sci. U.S.A., 90, 8000-4). The above ribozyme transcription units can be incorporated into a variety of vectors for introduction into mammalian cells, including but not restricted to, plasmid DNA vectors, viral DNA vectors (such as adenovirus or adeno-associated virus vectors), or viral RNA vectors (such as retroviral, Sindbis virus, Semliki forest virus vectors).

In a preferred embodiment of the invention, a transcription unit expressing a ribozyme that cleaves apo(a) RNA is inserted into a plasmid DNA vector, a retrovirus DNA viral vector, an adenovirus DNA viral vector or an adeno-associated virus vector. These and other vectors have been used to transfer genes to live animals (for a review see Friedman, 1989 Science 244, 1275-1281; Roemer and Friedman, 1992 Eur. J. Biochem. 208, 211-225) and leads to transient or stable gene expression. The vectors are delivered as recombinant viral particles. DNA may be delivered alone or complexed with vehicles (as described for RNA above). The DNA, DNA/vehicle complexes, or the recombinant virus particles are locally administered to the site of treatment, e.g., through the use of a catheter, stent or infusion pump.

EXAMPLE 1 apo(a) Hammerhead ribozymes

By engineering ribozyme motifs we have designed several ribozymes directed against apo(a) mRNA sequences. These have been synthesized with modifications that improve their nuclease resistance. These ribozymes cleave apo(a) target sequences in vitro.

The ribozymes will be tested for function in vivo by exogenous delivery to cells expressing apo(a). Ribozymes are delivered by incorporation into liposomes, by complexing with cationic lipids, by microinjection, or by expression from DNA vectors. Expression of apo(a) is monitored by ELISA, by indirect immunofluoresence, and/or by FACS analysis. Levels of apo(a) mRNA are assessed by Northern analysis, RNase protection, by primer extension analysis or by quantitative RT-PCR techniques. Ribozymes that block the induction of apo(a) protein and mRNA by more than 90% are identified.

Diagnostic uses

Ribozymes of this invention may be used as diagnostic tools to examine genetic drift and mutations within diseased cells. The close relationship between ribozyme activity and the structure of the target RNA allows the detection of mutations in any region of the molecule which alters the base-pairing and three-dimensional structure of the target RNA. By using multiple ribozymes described in this invention, one may map nucleotide changes which are important to RNA structure and function in vitro, as well as in cells and tissues. Cleavage of target RNAs with ribozymes may be used to inhibit gene expression and define the role (essentially) of specified gene products in the progression of disease. In this manner, other genetic targets may be defined as important mediators of the disease. These experiments will lead to better treatment of the disease progression by affording the possibility of combinational therapies (e.g., multiple ribozymes targeted to different genes, ribozymes coupled with known small molecule inhibitors, or intermittent treatment with combinations of ribozymes and/or other chemical or biological molecules). Other in vitro uses of ribozymes of this invention are well known in the art, and include detection of the presence of mRNA associated with an apo(a) related condition. Such RNA is detected by determining the presence of a cleavage product after treatment with a ribozyme using standard methodology.

In a specific example, ribozymes which can cleave only wild-type or mutant forms of the target RNA are used for the assay. The first ribozyme is used to identify wild-type RNA present in the sample and the second ribozyme will be used to identify mutant RNA in the sample. As reaction controls, synthetic substrates of both wild-type and mutant RNA will be cleaved by both ribozymes to demonstrate the relative ribozyme efficiencies in the reactions and the absence of cleavage of the "non-targeted" RNA species. The cleavage products from the synthetic substrates will also serve to generate size markers for the analysis of wild-type and mutant RNAs in the sample population. Thus each analysis will require two ribozymes, two substrates and one unknown sample which will be combined into six reactions. The presence of cleavage products will be determined using an RNAse protection assay so that full-length and cleavage fragments of each RNA can be analyzed in one lane of a polyacrylamide gel. It is not absolutely required to quantify the results to gain insight into the expression of mutant RNAs and putative risk of the desired phenotypic changes in target cells. The expression of mRNA whose protein product is implicated in the development of the phenotype (i.e., apo(a)) is adequate to establish risk. If probes of comparable specific activity are used for both transcripts, then a qualitative comparison of RNA levels will be adequate and will decrease the cost of the initial diagnosis. Higher mutant form to wild-type ratios will be correlated with higher risk whether RNA levels are compared qualitatively or quantitatively.

Other embodiments are within the following claims.

TABLE I Characteristics of Ribozymes

Group I Introns

Size: ˜200 to >1000 nucleotides.

Requires a U in the target sequence immediately 5' of the cleavage site.

Binds 4-6 nucleotides at 5' side of cleavage site.

Over 75 known members of this class. Found in Tetrahymena thermophila rRNA, fungal mitochondria, chloroplasts, phage T4, blue-green algae, and others.

RNAseP RNA (M1 RNA)

Size: ˜290 to 400 nucleotides.

RNA portion of a ribonucleoprotein enzyme. Cleaves tRNA precursors to form mature tRNA.

Roughly 10 known members of this group all are bacterial in origin.

Hammerhead Ribozyme

Size: ˜13 to 40 nucleotides.

Requires the target sequence UH immediately 5' of the cleavage site.

Binds a variable number nucleotides on both sides of the cleavage site.

14 known members of this class. Found in a number of plant pathogens (virusoids) that use RNA as the infectious agent (FIGS. 1 and 2)

Hairpin Ribozyme

Size: ˜50 nucleotides.

Requires the target sequence GUC immediately 3' of the cleavage site.

Binds 4-6 nucleotides at 5' side of the cleavage site and a variable number to the 3' side of the cleavage site.

Only 3 known member of this class. Found in three plant pathogen (satellite RNAs of the tobacco ringspot virus, arabis mosaic virus and chicory yellow mottle virus) which uses RNA as the infectious agent (FIG. 3).

Hepatitis Delta Virus (HDV) Ribozyme

Size: 50-60 nucleotides (at present).

Cleavage of target RNAs recently demonstrated.

Sequence requirements not fully determined.

Binding sites and structural requirements not fully determined, although no sequences 5' of cleavage site are required. Only 1 known member of this class. Found in human HDV (FIG. 4).

Neurospora VS RNA Ribozyme

Size: ˜144 nucleotides (at present)

Cleavage of target RNAs recently demonstrated.

Sequence requirements not fully determined.

Binding sites and structural requirements not fully determined. Only 1 known member of this class. Found in Neurospora VS RNA (FIG. 5).

                  TABLE II                                                         ______________________________________                                         Unique Human apo(a) HH Target sequence                                                                     SEQ ID                                             nt        HH Target Sequence                                                                               NO.                                                ______________________________________                                          127      CCAGGAU U GCUACCA  7                                                  151      ACAGAGU U AUCGAGG  8                                                  154      GAGUUAU C GAGGCAC  9                                                  199      CCAAGCU U GGUCAUC 10                                                  362      CAAUGCU C AGACGCA 11                                                  400      GACUGUU A CCCCGGU 12                                                  408      CCCCGGU U CCAAGCC 13                                                  409      CCCGGUU C CAAGCCU 14                                                  417      CAAGCCU A GAGGCUC 15                                                  481      CCAUGGU A AUGGACA 16                                                  571      GCAUAGU C GGACCCC 17                                                  9031     CCACGGU A AUGGACA 18                                                 10207     UCCAGAU C CUGUGGC 19                                                 10222     AGCCCCU U AUUGUUA 20                                                 10223     GCCCCUU A UUGUUAU 21                                                 10225     CCCUUAU U GUUAUAC 22                                                 10345     GGCUCCU U CUGAACA 23                                                 10346     GCUCCUU C UGAACAA 24                                                 10532     AAGAACU A CUGCCGA 25                                                 10543     CCGAAAU C CAGAUCC 26                                                 10564     AGCCCCU U GGUGUUA 27                                                 10570     UUGGUGU U AUACAAC 28                                                 10622     CGAUGCU C AGAUGCA 29                                                 10677     CAAGCCU A GAGGCUU 30                                                 10687     GGCUUUU U UUGAACA 31                                                 10736     UGCUACU A CCAUUAU 32                                                 10741     CUACCAU U AUGGACA 33                                                 10742     UACCAUU A UGGACAG 34                                                 10792     AAGAACU U GCCAAGC 35                                                 10828     CCAGCAU A GUCGGAC 36                                                 10899     CUGAGAU U CGCCCUU 37                                                 10900     UGAGAUU C GCCCUUG 38                                                 10906     UCGCCCU U GGUGUUA 39                                                 10924     CAUGGAU C CCAGUGU 40                                                 10976     ACAGAAU C AAGUGUC 41                                                 10983     CAAGUGU C CUUGCAA 42                                                 10986     GUGUCCU U GCAACUC 43                                                 11011     CCCAGAU C CAAGCAC 44                                                 11098     GAGUUAU C GAGGCUC 45                                                 11170     CUGGCAU C AGAGGAC 46                                                 11186     ACAGAAU A UUAUCCA 47                                                 11254     UUGGUGU U AUACCAU 48                                                 11257     GUGUUAU A CCAUGGA 49                                                 11266     CAUGGAU C CCAAUGU 50                                                 11305     ACAAUGU C CAGUGAC 51                                                 11347     GGCUGUU U CUGAACA 52                                                 11348     GCUGUUU C UGAACAA 53                                                 11423     CGAGGCU C AUUCUCC 54                                                 11427     GCUCAUU C UCCACCA 55                                                 11429     UCAUUCU C CACCACU 56                                                 11440     CACUGUU A CAGGAAG 57                                                 11653     CACAACU C CCACGGU 58                                                 11670     UCCCAGU U CCAAGCA 59                                                 11779     CACCACU A UCACAGG 60                                                 11797     AACAUGU C AGUCUUG 61                                                 11824     ACCACAU U GGCAUCG 62                                                 11988     GUGUCCU C ACAACUC 63                                                 12013     CCCGGUU C CAAGCAC 64                                                 12159     CUAUGAU A CCACACU 65                                                 12235     UCCAGAU U CUGGGAA 66                                                 12236     CCAGAUU C UGGGAAA 67                                                 12320     ACAGAAU C AGGUGUC 68                                                 12327     CAGGUGU C CUAGAGA 69                                                 12330     GUGUCCU A GAGACUC 70                                                 12337     AGAGACU C CCACUGU 71                                                 12374     GCUCAUU C UGAAGCA 72                                                 12453     GCACAUU C UCCACCA 73                                                 12481     GACAUGU C AAUCUUG 74                                                 12592     AGGCCCU U GGUGUUU 75                                                 12650     CGAUGCU C AGACACA 76                                                 12974     GCAUCCU C UUCAUUU 77                                                 12976     AUCCUCU U CAUUUGA 78                                                 13119     GCACCUU A AUAUCCC 79                                                 13226     CUCGAAU C UCAUGUU 80                                                 13228     CGAAUCU C AUGUUCA 81                                                 13839     UGGUAUU U UUGUGUA 82                                                 13848     UGUGUAU A AGCUUUU 83                                                 13930     ACUUAUU U UGAUUUG 84                                                 13931     CUUAUUU U GAUUUGA 85                                                 ______________________________________                                    

                                      TABLE III                                    __________________________________________________________________________     Unique Human apo(a) HH Ribozyme Sequence                                       nt.                                                                            position                                                                            Human apo(a) HH Ribozyme Sequence                                                                              SEQ ID NO.                                __________________________________________________________________________      127 UGGUAGC CUGAUGAGGCCGAAAGGCCGAA AUCCUGG                                                                          86                                        151 CCUCGAU CUGAUGAGGCCGAAAGGCCGAA ACUCUGU                                                                          87                                        154 GUGCCUC CUGAUGAGGCCGAAAGGCCGAA AUAACUC                                                                          88                                        199 GAUGACC CUGAUGAGGCCGAAAGGCCGAA AGCUUGG                                                                          89                                        362 UGCGUCU CUGAUGAGGCCGAAAGGCCGAA AGCAUUG                                                                          90                                        400 ACCGGGG CUGAUGAGGCCGAAAGGCCGAA AACAGUC                                                                          91                                        408 GGCUUGG CUGAUGAGGCCGAAAGGCCGAA ACCGGGG                                                                          92                                        409 AGGCUUG CUGAUGAGGCCGAAAGGCCGAA AACCGGG                                                                          93                                        417 GAGCCUC CUGAUGAGGCCGAAAGGCCGAA AGGCUUG                                                                          94                                        481 UGUCCAU CUGAUGAGGCCGAAAGGCCGAA ACCAUGG                                                                          95                                        571 GGGGUCC CUGAUGAGGCCGAAAGGCCGAA ACUAUGC                                                                          96                                        9031                                                                               UGUCCAU CUGAUGAGGCCGAAAGGCCGAA ACCGUGG                                                                          97                                       10207                                                                               GCCACAG CUGAUGAGGCCGAAAGGCCGAA AUCUGGA                                                                          98                                       10222                                                                               UAACAAU CUGAUGAGGCCGAAAGGCCGAA AGGGGCU                                                                          99                                       10223                                                                               AUAACAA CUGAUGAGGCCGAAAGGCCGAA AAGGGGC                                                                         100                                       10225                                                                               GUAUAAC CUGAUGAGGCCGAAAGGCCGAA AUAAGGG                                                                         101                                       10345                                                                               UGUUCAG CUGAUGAGGCCGAAAGGCCGAA AGGAGCC                                                                         102                                       10346                                                                               UUGUUCA CUGAUGAGGCCGAAAGGCCGAA AAGGAGC                                                                         103                                       10532                                                                               UCGGCAG CUGAUGAGGCCGAAAGGCCGAA AGUUCUU                                                                         104                                       10543                                                                               GGAUCUG CUGAUGAGGCCGAAAGGCCGAA AUUUCGG                                                                         105                                       10564                                                                               UAACACC CUGAUGAGGCCGAAAGGCCGAA AGGGGCU                                                                         106                                       10570                                                                               GUUGUAU CUGAUGAGGCCGAAAGGCCGAA ACACCAA                                                                         107                                       10622                                                                               UGCAUCU CUGAUGAGGCCGAAAGGCCGAA AGCAUCG                                                                         108                                       10677                                                                               AAGCCUC CUGAUGAGGCCGAAAGGCCGAA AGGCUUG                                                                         109                                       10687                                                                               UGUUCAA CUGAUGAGGCCGAAAGGCCGAA AAAAGCC                                                                         110                                       10736                                                                               AUAAUGG CUGAUGAGGCCGAAAGGCCGAA AGUAGCA                                                                         111                                       10741                                                                               UGUCCAU CUGAUGAGGCCGAAAGGCCGAA AUGGUAG                                                                         112                                       10742                                                                               CUGUCCA CUGAUGAGGCCGAAAGGCCGAA AAUGGUA                                                                         113                                       10792                                                                               GCUUGGC CUGAUGAGGCCGAAAGGCCGAA AGUUCUU                                                                         114                                       10828                                                                               GUCCGAC CUGAUGAGGCCGAAAGGCCGAA AUGCUGG                                                                         115                                       10899                                                                               AAGGGCG CUGAUGAGGCCGAAAGGCCGAA AUCUCAG                                                                         116                                       10900                                                                               CAAGGGC CUGAUGAGGCCGAAAGGCCGAA AAUCUCA                                                                         117                                       10906                                                                               UAACACC CUGAUGAGGCCGAAAGGCCGAA AGGGCGA                                                                         118                                       10924                                                                               ACACUGG CUGAUGAGGCCGAAAGGCCGAA AUCCAUG                                                                         119                                       10976                                                                               GACACUU CUGAUGAGGCCGAAAGGCCGAA AUUCUGU                                                                         120                                       10983                                                                               UUGCAAG CUGAUGAGGCCGAAAGGCCGAA ACACUUG                                                                         121                                       10986                                                                               GAGUUGC CUGAUGAGGCCGAAAGGCCGAA AGGACAC                                                                         122                                       11011                                                                               GUGCUUG CUGAUGAGGCCGAAAGGCCGAA AUCUGGG                                                                         123                                       11098                                                                               GAGCCUC CUGAUGAGGCCGAAAGGCCGAA AUAACUC                                                                         124                                       11170                                                                               GUCCUCU CUGAUGAGGCCGAAAGGCCGAA AUGCCAG                                                                         125                                       11186                                                                               UGGAUAA CUGAUGAGGCCGAAAGGCCGAA AUUCUGU                                                                         126                                       11254                                                                               AUGGUAU CUGAUGAGGCCGAAAGGCCGAA ACACCAA                                                                         127                                       11257                                                                               UCCAUGG CUGAUGAGGCCGAAAGGCCGAA AUAACAC                                                                         128                                       11266                                                                               ACAUUGG CUGAUGAGGCCGAAAGGCCGAA AUCCAUG                                                                         129                                       11305                                                                               GUCACUG CUGAUGAGGCCGAAAGGCCGAA ACAUUGU                                                                         130                                       11347                                                                               UGUUCAG CUGAUGAGGCCGAAAGGCCGAA AACAGCC                                                                         131                                       11348                                                                               UUGUUCA CUGAUGAGGCCGAAAGGCCGAA AAACAGC                                                                         132                                       11423                                                                               GGAGAAU CUGAUGAGGCCGAAAGGCCGAA AGCCUCG                                                                         133                                       11427                                                                               UGGUGGA CUGAUGAGGCCGAAAGGCCGAA AAUGAGC                                                                         134                                       11429                                                                               AGUGGUG CUGAUGAGGCCGAAAGGCCGAA AGAAUGA                                                                         135                                       11440                                                                               CUUCCUG CUGAUGAGGCCGAAAGGCCGAA AACAGUG                                                                         136                                       11653                                                                               ACCGUGG CUGAUGAGGCCGAAAGGCCGAA AGUUGUG                                                                         137                                       11670                                                                               UGCUUGG CUGAUGAGGCCGAAAGGCCGAA ACUGGGA                                                                         138                                       11779                                                                               CCUGUGA CUGAUGAGGCCGAAAGGCCGAA AGUGGUG                                                                         139                                       11797                                                                               CAAGACU CUGAUGAGGCCGAAAGGCCGAA ACAUGUU                                                                         140                                       11824                                                                               CGAUGCC CUGAUGAGGCCGAAAGGCCGAA AUGUGGU                                                                         141                                       11988                                                                               GAGUUGU CUGAUGAGGCCGAAAGGCCGAA AGGACAC                                                                         142                                       12013                                                                               GUGCUUG CUGAUGAGGCCGAAAGGCCGAA AACCGGG                                                                         143                                       12159                                                                               AGUGUGG CUGAUGAGGCCGAAAGGCCGAA AUCAUAG                                                                         144                                       12235                                                                               UUCCCAG CUGAUGAGGCCGAAAGGCCGAA AUCUGGA                                                                         145                                       12236                                                                               UUUCCCA CUGAUGAGGCCGAAAGGCCGAA AAUCUGG                                                                         146                                       12320                                                                               GACACCU CUGAUGAGGCCGAAAGGCCGAA AUUCUGU                                                                         147                                       12327                                                                               UCUCUAG CUGAUGAGGCCGAAAGGCCGAA ACACCUG                                                                         148                                       12330                                                                               GAGUCUC CUGAUGAGGCCGAAAGGCCGAA AGGACAC                                                                         149                                       12337                                                                               ACAGUGG CUGAUGAGGCCGAAAGGCCGAA AGUCUCU                                                                         150                                       12374                                                                               UGCUUCA CUGAUGAGGCCGAAAGGCCGAA AAUGAGC                                                                         151                                       12453                                                                               UGGUGGA CUGAUGAGGCCGAAAGGCCGAA AAUGUGC                                                                         152                                       12481                                                                               CAAGAUU CUGAUGAGGCCGAAAGGCCGAA ACAUGUC                                                                         153                                       12592                                                                               AAACACC CUGAUGAGGCCGAAAGGCCGAA AGGGCCU                                                                         154                                       12650                                                                               UGUGUCU CUGAUGAGGCCGAAAGGCCGAA AGCAUCG                                                                         155                                       12974                                                                               AAAUGAA CUGAUGAGGCCGAAAGGCCGAA AGGAUGC                                                                         156                                       12976                                                                               UCAAAUG CUGAUGAGGCCGAAAGGCCGAA AGAGGAU                                                                         157                                       13119                                                                               GGGAUAU CUGAUGAGGCCGAAAGGCCGAA AAGGUGC                                                                         158                                       13226                                                                               AACAUGA CUGAUGAGGCCGAAAGGCCGAA AUUCGAG                                                                         159                                       13228                                                                               UGAACAU CUGAUGAGGCCGAAAGGCCGAA AGAUUCG                                                                         160                                       13839                                                                               UACACAA CUGAUGAGGCCGAAAGGCCGAA AAUACCA                                                                         161                                       13848                                                                               AAAAGCU CUGAUGAGGCCGAAAGGCCGAA AUACACA                                                                         162                                       13930                                                                               CAAAUCA CUGAUGAGGCCGAAAGGCCGAA AAUAAGU                                                                         163                                       13931                                                                               UCAAAUC CUGAUGAGGCCGAAAGGCCGAA AAAUAAG                                                                         164                                       __________________________________________________________________________

                  TABLE IV                                                         ______________________________________                                         Unique Monkey apo(a) HH Target Sequence                                                  HH Target         SEQ ID                                             nt.       Sequence          NO.                                                ______________________________________                                          127      CUGCCGU C GCaCCUC 165                                                 151      CUGCCGU C GCaCCUC 166                                                 154      CUGCCgU C GcaCCUC 167                                                 199      CCCCGGU U CCAAGCC 168                                                 362      AGAGGCU C CUUCCGA 169                                                 400      GGCUCCU U CCGAACA 170                                                 408      GGCUCCU U CCGAACA 171                                                 409      GGCUCCU U CCGAACA 172                                                 417      GGCUCCU U CCGAACA 173                                                 481      GCUCCUU C CGAACAA 174                                                 571      ACAGAGU U AUCGAGG 175                                                 9031     GAGUUAU C GAGGCAc 176                                                10207     CCACACU C uCAUAGU 177                                                10222     CCACACU C uCAUAGU 178                                                10223     AGAGGCU C CUUCUGA 179                                                10225     AGAGGCU c CUUCUGA 180                                                10345     GUGUUAU A CAACgGA 181                                                10346     AACgGAU C CCAGUGU 182                                                10532     AGaGGcU u UUCUuga 183                                                10543     AGAGGCU U UUcUUGA 184                                                10564     GAGGCuU u UCuUgaA 185                                                10570     AGGCUUU U cUUGAAC 186                                                10622     UgCUACU a CcaUUAU 187                                                10677     GGCACAU A CUCCACC 188                                                10687     CCACUGU u ACAGGAA 189                                                10736     ccACUGU u ACAGGAA 190                                                10741     CCACUGU u ACAGGAA 191                                                10742     CCACUGU u ACAGGAA 192                                                10792     CACUGUU A CaGGaAg 193                                                10828     GCAUAGU C GGACCCC 194                                                10899     GCAUAGU C GGACCCC 195                                                10900     GCAUAGU C GGACCCC 196                                                10906     AaAaACU a UCcaaAu 197                                                10924     CAGGAAU C CAGAUGC 198                                                10976     CAGGAAU C CAGAUGC 199                                                10983     CAGGAAU C CAGAUGC 200                                                10986     CAGGAAU C CAGAUGC 201                                                11011     CAGGAAU C CAGAUGC 202                                                11098     UcGcCCU U GGUGUUA 203                                                11170     ACAaUgU C UGGugAC 204                                                11186     ACAGAAU C AAGUGUC 205                                                11254     gCUUcUU c UgaAGAA 206                                                11257     GACUGCU A CCAUGGU 207                                                11266     GAGUUAU C GAGGCUC 208                                                11305     CGAGGCU C AUUCUCC 209                                                11347     UCAUUCU C CACCACU 210                                                11348     GACAUGU C AGUCUUG 211                                                11423     UCUUGGU C CUCUAUG 212                                                11427     UGGUCCU C UAUGACA 213                                                11429     UGGUCCU C UAUGACA 214                                                11440     GUCCUCU A UGACACC 215                                                11653     auAGAAU A CUACCCA 216                                                11670     auAGAAU A CUACCCA 217                                                11779     aUGgAaU c AaGUGUC 218                                                11797     CAAGUGU C CUUGCaA 219                                                11824     UCCCAGU U CCAAGCA 220                                                11988     UcGGCAU C GGAGGAU 221                                                12013     UCCCAUU A cgCUAUC 222                                                12159     GCUCCUU C UGAACAA 223                                                12235     CCAGGAU U GCUACCA 224                                                12236     CCAGGAU U GCUACCA 225                                                12320     gaACUGU c aGUcUuG 226                                                12327     UCUUGGU C AUCUAUG 227                                                12330     UGGUCAU C UAUGAUA 228                                                12337     GUCAUCU A UGAUACC 229                                                12374     UGGUGUU A CACgACu 230                                                12453     AgagaCU c CCACUGU 231                                                12481     CUGUUGU U CCgGUUC 232                                                12592     GCUCAUU C UGAAGCA 233                                                12650     UCAAUCU U GGUCAUC 234                                                12974     CCACAUU C CUGGCCC 235                                                12976     GGCAAGU C AGUCUuA 236                                                13119     AgGccuU c CUUCUAC 237                                                13226     AGUGUCU A GGuUGUU 238                                                13228     aGuGUCU a GGuUGUu 239                                                13839     UGGUAUU a UUGUGUA 240                                                13848     UAAGCUU U UcccGUC 241                                                ______________________________________                                    

                                      TABLE V                                      __________________________________________________________________________     Unique Monkey apo(a) HH Ribozyme Sequence                                      nt.  Monkey HH Ribozyme Sequence     SEQ ID NO.                                __________________________________________________________________________      127 GAGGUGC CUGAUGAGGCCGAAAGGCCGAA ACGGCAG                                                                         242                                        151 GAGGUGC CUGAUGAGGCCGAAAGGCCGAA ACGGCAG                                                                         243                                        154 GAGGUGC CUGAUGAGGCCGAAAGGCCGAA ACGGCAG                                                                         244                                        199 GGCUUGG CUGAUGAGGCCGAAAGGCCGAA ACCGGGG                                                                         245                                        362 UCGGAAG CUGAUGAGGCCGAAAGGCCGAA AGCCUCU                                                                         246                                        400 UGUUCGG CUGAUGAGGCCGAAAGGCCGAA AGGAGCC                                                                         247                                        408 UGUUCGG CUGAUGAGGCCGAAAGGCCGAA AGGAGCC                                                                         248                                        409 UGUUCGG CUGAUGAGGCCGAAAGGCCGAA AGGAGCC                                                                         249                                        417 UGUUCGG CUGAUGAGGCCGAAAGGCCGAA AGGAGCC                                                                         250                                        481 UUGUUCG CUGAUGAGGCCGAAAGGCCGAA AAGGAGC                                                                         251                                        571 CCUCGAU CUGAUGAGGCCGAAAGGCCGAA ACUCUGU                                                                         252                                        9031                                                                               GUGCCUC CUGAUGAGGCCGAAAGGCCGAA AUAACUC                                                                         253                                       10207                                                                               ACUAUGA CUGAUGAGGCCGAAAGGCCGAA AGUGUGG                                                                         254                                       10222                                                                               ACUAUGA CUGAUGAGGCCGAAAGGCCGAA AGUGUGG                                                                         255                                       10223                                                                               UCAGAAG CUGAUGAGGCCGAAAGGCCGAA AGCCUCU                                                                         256                                       10225                                                                               UCAGAAG CUGAUGAGGCCGAAAGGCCGAA AGCCUCU                                                                         257                                       10345                                                                               UCCGUUG CUGAUGAGGCCGAAAGGCCGAA AUAACAC                                                                         258                                       10346                                                                               ACACUGG CUGAUGAGGCCGAAAGGCCGAA AUCCGUU                                                                         259                                       10532                                                                               UCAAGAA CUGAUGAGGCCGAAAGGCCGAA AGCCUCU                                                                         260                                       10543                                                                               UCAAGAA CUGAUGAGGCCGAAAGGCCGAA AGCCUCU                                                                         261                                       10564                                                                               UUCAAGA CUGAUGAGGCCGAAAGGCCGAA AAGCCUC                                                                         262                                       10570                                                                               GUUCAAG CUGAUGAGGCCGAAAGGCCGAA AAAGCCU                                                                         263                                       10622                                                                               AUAAUGG CUGAUGAGGCCGAAAGGCCGAA AGUAGCA                                                                         264                                       10677                                                                               GGUGGAG CUGAUGAGGCCGAAAGGCCGAA AUGUGCC                                                                         265                                       10687                                                                               UUCCUGU CUGAUGAGGCCGAAAGGCCGAA ACAGUGG                                                                         266                                       10736                                                                               UUCCUGU CUGAUGAGGCCGAAAGGCCGAA ACAGUGG                                                                         267                                       10741                                                                               UUCCUGU CUGAUGAGGCCGAAAGGCCGAA ACAGUGG                                                                         268                                       10742                                                                               UUCCUGU CUGAUGAGGCCGAAAGGCCGAA ACAGUGG                                                                         269                                       10792                                                                               CUUCCUG CUGAUGAGGCCGAAAGGCCGAA AACAGUG                                                                         270                                       10828                                                                               GGGGUCC CUGAUGAGGCCGAAAGGCCGAA ACUAUGC                                                                         271                                       10899                                                                               GGGGUCC CUGAUGAGGCCGAAAGGCCGAA ACUAUGC                                                                         272                                       10900                                                                               GGGGUCC CUGAUGAGGCCGAAAGGCCGAA ACUAUGC                                                                         273                                       10906                                                                               AUUUGGA CUGAUGAGGCCGAAAGGCCGAA AGUUUUU                                                                         274                                       10924                                                                               GCAUCUG CUGAUGAGGCCGAAAGGCCGAA AUUCCUG                                                                         275                                       10976                                                                               GCAUCUG CUGAUGAGGCCGAAAGGCCGAA AUUCCUG                                                                         276                                       10983                                                                               GCAUCUG CUGAUGAGGCCGAAAGGCCGAA AUUCCUG                                                                         277                                       10986                                                                               GCAUCUG CUGAUGAGGCCGAAAGGCCGAA AUUCCUG                                                                         278                                       11011                                                                               GCAUCUG CUGAUGAGGCCGAAAGGCCGAA AUUCCUG                                                                         279                                       11098                                                                               UAACACC CUGAUGAGGCCGAAAGGCCGAA AGGGCGA                                                                         280                                       11170                                                                               GUCACCA CUGAUGAGGCCGAAAGGCCGAA ACAUUGU                                                                         281                                       11186                                                                               GACACUU CUGAUGAGGCCGAAAGGCCGAA AUUCUGU                                                                         282                                       11254                                                                               UUCUUCA CUGAUGAGGCCGAAAGGCCGAA AAGAAGC                                                                         283                                       11257                                                                               ACCAUGG CUGAUGAGGCCGAAAGGCCGAA AGCAGUC                                                                         284                                       11266                                                                               GAGCCUC CUGAUGAGGCCGAAAGGCCGAA AUAACUC                                                                         285                                       11305                                                                               GGAGAAU CUGAUGAGGCCGAAAGGCCGAA AGCCUCG                                                                         286                                       11347                                                                               AGUGGUG CUGAUGAGGCCGAAAGGCCGAA AGAAUGA                                                                         287                                       11348                                                                               CAAGACU CUGAUGAGGCCGAAAGGCCGAA ACAUGUC                                                                         288                                       11423                                                                               CAUAGAG CUGAUGAGGCCGAAAGGCCGAA ACCAAGA                                                                         289                                       11427                                                                               UGUCAUA CUGAUGAGGCCGAAAGGCCGAA AGGACCA                                                                         290                                       11429                                                                               UGUCAUA CUGAUGAGGCCGAAAGGCCGAA AGGACCA                                                                         291                                       11440                                                                               GGUGUCA CUGAUGAGGCCGAAAGGCCGAA AGAGGAC                                                                         292                                       11653                                                                               UGGGUAG CUGAUGAGGCCGAAAGGCCGAA AUUCUAU                                                                         293                                       11670                                                                               UGGGUAG CUGAUGAGGCCGAAAGGCCGAA AUUCUAU                                                                         294                                       11779                                                                               GACACUU CUGAUGAGGCCGAAAGGCCGAA AUUCCAU                                                                         295                                       11797                                                                               UUGCAAG CUGAUGAGGCCGAAAGGCCGAA ACACUUG                                                                         296                                       11824                                                                               UGCUUGG CUGAUGAGGCCGAAAGGCCGAA ACUGGGA                                                                         297                                       11988                                                                               AUCCUCC CUGAUGAGGCCGAAAGGCCGAA AUGCCGA                                                                         298                                       12013                                                                               GAUAGCG CUGAUGAGGCCGAAAGGCCGAA AAUGGGA                                                                         299                                       12159                                                                               UUGUUCA CUGAUGAGGCCGAAAGGCCGAA AAGGAGC                                                                         300                                       12235                                                                               UGGUAGC CUGAUGAGGCCGAAAGGCCGAA AUCCUGG                                                                         301                                       12236                                                                               UGGUAGC CUGAUGAGGCCGAAAGGCCGAA AUCCUGG                                                                         302                                       12320                                                                               CAAGACU CUGAUGAGGCCGAAAGGCCGAA ACAGUUC                                                                         303                                       12327                                                                               CAUAGAU CUGAUGAGGCCGAAAGGCCGAA ACCAAGA                                                                         304                                       12330                                                                               UAUCAUA CUGAUGAGGCCGAAAGGCCGAA AUGACCA                                                                         305                                       12337                                                                               GGUAUCA CUGAUGAGGCCGAAAGGCCGAA AGAUGAC                                                                         306                                       12374                                                                               AGUCGUG CUGAUGAGGCCGAAAGGCCGAA AACACCA                                                                         307                                       12453                                                                               ACAGUGG CUGAUGAGGCCGAAAGGCCGAA AGUCUCU                                                                         308                                       12481                                                                               GAACCGG CUGAUGAGGCCGAAAGGCCGAA ACAACAG                                                                         309                                       12592                                                                               UGCUUCA CUGAUGAGGCCGAAAGGCCGAA AAUGAGC                                                                         310                                       12650                                                                               GAUGACC CUGAUGAGGCCGAAAGGCCGAA AGAUUGA                                                                         311                                       12974                                                                               GGGCCAG CUGAUGAGGCCGAAAGGCCGAA AAUGUGG                                                                         312                                       12976                                                                               UAAGACU CUGAUGAGGCCGAAAGGCCGAA ACUUGCC                                                                         313                                       13119                                                                               GUAGAAG CUGAUGAGGCCGAAAGGCCGAA AAGGCCU                                                                         314                                       13226                                                                               AACAACC CUGAUGAGGCCGAAAGGCCGAA AGACACU                                                                         315                                       13228                                                                               AACAACC CUGAUGAGGCCGAAAGGCCGAA AGACACU                                                                         316                                       13839                                                                               UACACAA CUGAUGAGGCCGAAAGGCCGAA AAUACCA                                                                         317                                       13848                                                                               GACGGGA CUGAUGAGGCCGAAAGGCCGAA AAGCUUA                                                                         318                                       __________________________________________________________________________

                                      TABLE VI                                     __________________________________________________________________________     Unique Human apo(a) Hairpin Ribozyme Sequence                                  __________________________________________________________________________     nt. Hairpin Ribozyme Sequence               SEQ ID NO.                         __________________________________________________________________________      378                                                                               GGCGCGAC AGAA GUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                319                                 381                                                                               GGAGGCGC AGAA GCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                320                                 440                                                                               UUUGCUCA AGAA GUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                321                                 7964                                                                              UCUGCUCA AGAA GUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                322                                10215                                                                              CAAUAAGG AGAA GCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                323                                10534                                                                              UGGAUUUC AGAA GUAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                324                                10557                                                                              CACCAAGG AGAA GCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                325                                10638                                                                              GGGACGAA AGAA GUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                326                                10700                                                                              UUUCCUCA AGAA GUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                327                                11343                                                                              UGUUCAGA AGAA GCCG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                328                                11379                                                                              CAGUCCUG AGAA GUGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                329                                12342                                                                              ACUGGAAC AGAA GUGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                330                                12804                                                                              GGCUCCUG AGAA GCCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                331                                12877                                                                              AGGGUUAC AGAA GUAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                332                                13139                                                                              GAGCAGCA AGAA GCAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                333                                13256                                                                              GCUCCAAG AGAA GCCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                334                                13522                                                                              ACCCUGGC AGAA GUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                335                                13794                                                                              UAGCUGGG AGAA GUGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                336                                __________________________________________________________________________                                nt. Substrate Sequence                                                                          SEQ ID NO.                         __________________________________________________________________________                                 378                                                                               GGACU GCC GUCGCGCC                                                                          337                                                            381                                                                               CUGCC GUC GCGCCUCC                                                                          338                                                            440                                                                               GCACC GAC UGAGCAAA                                                                          339                                                            7964                                                                              GCACC GAC UGAGCAGA                                                                          340                                                           10215                                                                              UGGCA GCC CCUUAUUG                                                                          341                                                           10534                                                                              CUACU GCC GAAAUCCA                                                                          342                                                           10557                                                                              UGGCA GCC CCUUGGUG                                                                          343                                                           10638                                                                              GGACU GCC UUCGUCCC                                                                          344                                                           10700                                                                              GCACU GAC UGAGGAAA                                                                          345                                                           11343                                                                              CGGCU GUU UCUGAACA                                                                          346                                                           11379                                                                              CCACA GUC CAGGACUG                                                                          347                                                           12342                                                                              CCACU GUU GUUCCAGU                                                                          348                                                           12804                                                                              GGGCU GCC CAGGAGCC                                                                          349                                                           12877                                                                              UUACU GCC GUAACCCU                                                                          350                                                           13139                                                                              GUGCU GAC UGCUGCUC                                                                          351                                                           13256                                                                              AGGCU GUU CUUGGAGC                                                                          352                                                           13522                                                                              UGACA GUU GCCAGGGU                                                                          353                                                           13794                                                                              ACACU GUU CCCAGCUA                                                                          354                                __________________________________________________________________________

                                      TABLE VII                                    __________________________________________________________________________     Unique Monkey apo(a) Hairpin Ribozyme Sequence                                 __________________________________________________________________________     nt. Hairpin Ribozyme Sequence               SEQ ID NO.                         __________________________________________________________________________      57 GGUGCGAC AGAA GUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                355                                 60 GGAGGUGC AGAA GCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                356                                 119                                                                               UUUGCUCA AGAA GUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                357                                 318                                                                               CAAUAAGG AGAA GCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                358                                 660                                                                               CAAUAAGG AGAA GCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                359                                 744                                                                               GGAGGUGC AGAA GCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                360                                 803                                                                               UUUGCUCA AGAA GUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                361                                1002                                                                               CAAUAAGG AGAA GCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                362                                1083                                                                               GGUGCGAC AGAA GUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                363                                1086                                                                               GGAGGUGC AGAA GCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                364                                1321                                                                               UGGAUUUC AGAA GUAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                365                                1344                                                                               CACCAAGG AGAA GCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                366                                2130                                                                               UGUUCAGA AGAA GCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                367                                2500                                                                               GACCCCAG AGAA GUUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                368                                3129                                                                               ACCGGAAC AGAA GUGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                369                                3683                                                                               AAGCAGCA AGAA GCAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                370                                3890                                                                               AAUUUGGA AGAA GCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                371                                3912                                                                               UCAGUCCA AGAA GUGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                372                                4365                                                                               UAGCUGGG AGAA GUGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                                373                                __________________________________________________________________________                                nt. Substrate Sequence                                                                          SEQ ID NO.                         __________________________________________________________________________                                 57 GGACU GCC GUCGCACC                                                                          374                                                            60 CUGCC GUC GCACCUCC                                                                          375                                                            119                                                                               GCACC GAC UGAGCAAA                                                                          376                                                            318                                                                               UGGCA GCC CCUUAUUG                                                                          377                                                            660                                                                               UGGCA GCC CCUUAUUG                                                                          378                                                            744                                                                               CUGCA GUC GCACCUCC                                                                          379                                                            803                                                                               GCACC GAC UGAGCAAA                                                                          380                                                           1002                                                                               UGGCA GCC CCUUAUUG                                                                          381                                                           1083                                                                               GGACU GCC GUCGCACC                                                                          382                                                           1086                                                                               CUGCC GUC GCACCUCC                                                                          383                                                           1321                                                                               CUACU GCC GAAAUCCA                                                                          384                                                           1344                                                                               UGGCA GCC CCUUGGUG                                                                          385                                                           2130                                                                               UGGCU GUU UCUGAACA                                                                          386                                                           2500                                                                               AAACA GCC CUGGGGUC                                                                          387                                                           3129                                                                               CCACU GUU GUUCCGGU                                                                          388                                                           3683                                                                               GUGCU GAC UGCUGCUU                                                                          389                                                           3890                                                                               CUGCC GUC UCCAAAUU                                                                          390                                                           3912                                                                               UCACC GCC UGGACUGA                                                                          391                                                           4365                                                                               ACACU GUC CCCAGCUA                                                                          392                                __________________________________________________________________________

    __________________________________________________________________________     SEQUENCE LISTING                                                               (1) GENERAL INFORMATION:                                                       (iii) NUMBER OF SEQUENCES: 392                                                 (2) INFORMATION FOR SEQ ID NO:1:                                               (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 11 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (ix) FEATURE:                                                                  (D) OTHER INFORMATION: The letter "N"stands for any                            base. The letter "H"stands for                                                 A, U, or C.                                                                    (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1:                                        NNNNUHNNNNN11                                                                  (2) INFORMATION FOR SEQ ID NO:2:                                               (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 28 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (ix) FEATURE:                                                                  (D) OTHER INFORMATION: The letter "N"stands for any base.                      (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2:                                        NNNNNCUGANGAGNNNNNNCGAAANNNN28                                                 (2) INFORMATION FOR SEQ ID NO:3:                                               (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 14 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (ix) FEATURE:                                                                  (D) OTHER INFORMATION: The letter "N"stands for any                            base. The leter "Y"stands for                                                  U or C. The letter "H"stands                                                   for A, U, or C.                                                                (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3:                                        NNNYNGHYNNNNNN14                                                               (2) INFORMATION FOR SEQ ID NO:4:                                               (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 50 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (ix) FEATURE:                                                                  (D) OTHER INFORMATION: The letter "N"stands for any                            base.                                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4:                                        NNNNNNNGAAGNNNNNNNNNNAAACANNNNNNNNNNNACAUUACNNNNNN50                           (2) INFORMATION FOR SEQ ID NO:5:                                               (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 85 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5:                                        UGGCCGGCAUGGUCCCAGCCUCCUCGCUGGCGCCGGCUGGGCAACAUUCCGAGGGGACCG60                 UCCCCUCGGUAAUGGCGAAUGGGAC85                                                    (2) INFORMATION FOR SEQ ID NO:6:                                               (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 176 base pairs                                                     (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6:                                        GGGAAAGCUUGCGAAGGGCGUCGUCGCCCCGAGCGGUAGUAAGCAGGGAACUCACCUCCA60                 AUUUCAGUACUGAAAUUGUCGUAGCAGUUGACUACUGUUAUGUGAUUGGUAGAGGCUAAG120                UGACGGUAUUGGCGUAAGUCAGUAUUGCAGCACAGCACAAGCCCGCUUGCGAGAAU176                    (2) INFORMATION FOR SEQ ID NO:7:                                               (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7:                                        CCAGGAUUGCUACCA15                                                              (2) INFORMATION FOR SEQ ID NO:8:                                               (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8:                                        ACAGAGUUAUCGAGG15                                                              (2) INFORMATION FOR SEQ ID NO:9:                                               (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9:                                        GAGUUAUCGAGGCAC15                                                              (2) INFORMATION FOR SEQ ID NO:10:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10:                                       CCAAGCUUGGUCAUC15                                                              (2) INFORMATION FOR SEQ ID NO:11:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11:                                       CAAUGCUCAGACGCA15                                                              (2) INFORMATION FOR SEQ ID NO:12:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12:                                       GACUGUUACCCCGGU15                                                              (2) INFORMATION FOR SEQ ID NO:13:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13:                                       CCCCGGUUCCAAGCC15                                                              (2) INFORMATION FOR SEQ ID NO:14:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14:                                       CCCGGUUCCAAGCCU15                                                              (2) INFORMATION FOR SEQ ID NO:15:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15:                                       CAAGCCUAGAGGCUC15                                                              (2) INFORMATION FOR SEQ ID NO:16:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16:                                       CCAUGGUAAUGGACA15                                                              (2) INFORMATION FOR SEQ ID NO:17:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17:                                       GCAUAGUCGGACCCC15                                                              (2) INFORMATION FOR SEQ ID NO:18:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18:                                       CCACGGUAAUGGACA15                                                              (2) INFORMATION FOR SEQ ID NO:19:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19:                                       UCCAGAUCCUGUGGC15                                                              (2) INFORMATION FOR SEQ ID NO:20:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20:                                       AGCCCCUUAUUGUUA15                                                              (2) INFORMATION FOR SEQ ID NO:21:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21:                                       GCCCCUUAUUGUUAU15                                                              (2) INFORMATION FOR SEQ ID NO:22:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22:                                       CCCUUAUUGUUAUAC15                                                              (2) INFORMATION FOR SEQ ID NO:23:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23:                                       GGCUCCUUCUGAACA15                                                              (2) INFORMATION FOR SEQ ID NO:24:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24:                                       GCUCCUUCUGAACAA15                                                              (2) INFORMATION FOR SEQ ID NO:25:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25:                                       AAGAACUACUGCCGA15                                                              (2) INFORMATION FOR SEQ ID NO:26:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26:                                       CCGAAAUCCAGAUCC15                                                              (2) INFORMATION FOR SEQ ID NO:27:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27:                                       AGCCCCUUGGUGUUA15                                                              (2) INFORMATION FOR SEQ ID NO:28:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28:                                       UUGGUGUUAUACAAC15                                                              (2) INFORMATION FOR SEQ ID NO:29:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29:                                       CGAUGCUCAGAUGCA15                                                              (2) INFORMATION FOR SEQ ID NO:30:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:30:                                       CAAGCCUAGAGGCUU15                                                              (2) INFORMATION FOR SEQ ID NO:31:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:31:                                       GGCUUUUUUUGAACA15                                                              (2) INFORMATION FOR SEQ ID NO:32:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32:                                       UGCUACUACCAUUAU15                                                              (2) INFORMATION FOR SEQ ID NO:33:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33:                                       CUACCAUUAUGGACA15                                                              (2) INFORMATION FOR SEQ ID NO:34:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:34:                                       UACCAUUAUGGACAG15                                                              (2) INFORMATION FOR SEQ ID NO:35:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:35:                                       AAGAACUUGCCAAGC15                                                              (2) INFORMATION FOR SEQ ID NO:36:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36:                                       CCAGCAUAGUCGGAC15                                                              (2) INFORMATION FOR SEQ ID NO:37:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37:                                       CUGAGAUUCGCCCUU15                                                              (2) INFORMATION FOR SEQ ID NO:38:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38:                                       UGAGAUUCGCCCUUG15                                                              (2) INFORMATION FOR SEQ ID NO:39:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39:                                       UCGCCCUUGGUGUUA15                                                              (2) INFORMATION FOR SEQ ID NO:40:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:40:                                       CAUGGAUCCCAGUGU15                                                              (2) INFORMATION FOR SEQ ID NO:41:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41:                                       ACAGAAUCAAGUGUC15                                                              (2) INFORMATION FOR SEQ ID NO:42:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42:                                       CAAGUGUCCUUGCAA15                                                              (2) INFORMATION FOR SEQ ID NO:43:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43:                                       GUGUCCUUGCAACUC15                                                              (2) INFORMATION FOR SEQ ID NO:44:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44:                                       CCCAGAUCCAAGCAC15                                                              (2) INFORMATION FOR SEQ ID NO:45:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:45:                                       GAGUUAUCGAGGCUC15                                                              (2) INFORMATION FOR SEQ ID NO:46:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46:                                       CUGGCAUCAGAGGAC15                                                              (2) INFORMATION FOR SEQ ID NO:47:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47:                                       ACAGAAUAUUAUCCA15                                                              (2) INFORMATION FOR SEQ ID NO:48:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48:                                       UUGGUGUUAUACCAU15                                                              (2) INFORMATION FOR SEQ ID NO:49:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49:                                       GUGUUAUACCAUGGA15                                                              (2) INFORMATION FOR SEQ ID NO:50:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:50:                                       CAUGGAUCCCAAUGU15                                                              (2) INFORMATION FOR SEQ ID NO:51:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51:                                       ACAAUGUCCAGUGAC15                                                              (2) INFORMATION FOR SEQ ID NO:52:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:52:                                       GGCUGUUUCUGAACA15                                                              (2) INFORMATION FOR SEQ ID NO:53:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:53:                                       GCUGUUUCUGAACAA15                                                              (2) INFORMATION FOR SEQ ID NO:54:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:54:                                       CGAGGCUCAUUCUCC15                                                              (2) INFORMATION FOR SEQ ID NO:55:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:55:                                       GCUCAUUCUCCACCA15                                                              (2) INFORMATION FOR SEQ ID NO:56:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:56:                                       UCAUUCUCCACCACU15                                                              (2) INFORMATION FOR SEQ ID NO:57:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:57:                                       CACUGUUACAGGAAG15                                                              (2) INFORMATION FOR SEQ ID NO:58:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:58:                                       CACAACUCCCACGGU15                                                              (2) INFORMATION FOR SEQ ID NO:59:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:59:                                       UCCCAGUUCCAAGCA15                                                              (2) INFORMATION FOR SEQ ID NO:60:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:60:                                       CACCACUAUCACAGG15                                                              (2) INFORMATION FOR SEQ ID NO:61:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:61:                                       AACAUGUCAGUCUUG15                                                              (2) INFORMATION FOR SEQ ID NO:62:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:62:                                       ACCACAUUGGCAUCG15                                                              (2) INFORMATION FOR SEQ ID NO:63:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:63:                                       GUGUCCUCACAACUC15                                                              (2) INFORMATION FOR SEQ ID NO:64:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:64:                                       CCCGGUUCCAAGCAC15                                                              (2) INFORMATION FOR SEQ ID NO:65:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:65:                                       CUAUGAUACCACACU15                                                              (2) INFORMATION FOR SEQ ID NO:66:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:66:                                       UCCAGAUUCUGGGAA15                                                              (2) INFORMATION FOR SEQ ID NO:67:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:67:                                       CCAGAUUCUGGGAAA15                                                              (2) INFORMATION FOR SEQ ID NO:68:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:68:                                       ACAGAAUCAGGUGUC15                                                              (2) INFORMATION FOR SEQ ID NO:69:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:69:                                       CAGGUGUCCUAGAGA15                                                              (2) INFORMATION FOR SEQ ID NO:70:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:70:                                       GUGUCCUAGAGACUC15                                                              (2) INFORMATION FOR SEQ ID NO:71:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:71:                                       AGAGACUCCCACUGU15                                                              (2) INFORMATION FOR SEQ ID NO:72:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:72:                                       GCUCAUUCUGAAGCA15                                                              (2) INFORMATION FOR SEQ ID NO:73:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:73:                                       GCACAUUCUCCACCA15                                                              (2) INFORMATION FOR SEQ ID NO:74:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:74:                                       GACAUGUCAAUCUUG15                                                              (2) INFORMATION FOR SEQ ID NO:75:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:75:                                       AGGCCCUUGGUGUUU15                                                              (2) INFORMATION FOR SEQ ID NO:76:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:76:                                       CGAUGCUCAGACACA15                                                              (2) INFORMATION FOR SEQ ID NO:77:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:77:                                       GCAUCCUCUUCAUUU15                                                              (2) INFORMATION FOR SEQ ID NO:78:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:78:                                       AUCCUCUUCAUUUGA15                                                              (2) INFORMATION FOR SEQ ID NO:79:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:79:                                       GCACCUUAAUAUCCC15                                                              (2) INFORMATION FOR SEQ ID NO:80:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:80:                                       CUCGAAUCUCAUGUU15                                                              (2) INFORMATION FOR SEQ ID NO:81:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:81:                                       CGAAUCUCAUGUUCA15                                                              (2) INFORMATION FOR SEQ ID NO:82:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:82:                                       UGGUAUUUUUGUGUA15                                                              (2) INFORMATION FOR SEQ ID NO:83:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:83:                                       UGUGUAUAAGCUUUU15                                                              (2) INFORMATION FOR SEQ ID NO:84:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:84:                                       ACUUAUUUUGAUUUG15                                                              (2) INFORMATION FOR SEQ ID NO:85:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:85:                                       CUUAUUUUGAUUUGA15                                                              (2) INFORMATION FOR SEQ ID NO:86:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:86:                                       UGGUAGCCUGAUGAGGCCGAAAGGCCGAAAUCCUGG36                                         (2) INFORMATION FOR SEQ ID NO:87:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:87:                                       CCUCGAUCUGAUGAGGCCGAAAGGCCGAAACUCUGU36                                         (2) INFORMATION FOR SEQ ID NO:88:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:88:                                       GUGCCUCCUGAUGAGGCCGAAAGGCCGAAAUAACUC36                                         (2) INFORMATION FOR SEQ ID NO:89:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:89:                                       GAUGACCCUGAUGAGGCCGAAAGGCCGAAAGCUUGG36                                         (2) INFORMATION FOR SEQ ID NO:90:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:90:                                       UGCGUCUCUGAUGAGGCCGAAAGGCCGAAAGCAUUG36                                         (2) INFORMATION FOR SEQ ID NO:91:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:91:                                       ACCGGGGCUGAUGAGGCCGAAAGGCCGAAAACAGUC36                                         (2) INFORMATION FOR SEQ ID NO:92:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:92:                                       GGCUUGGCUGAUGAGGCCGAAAGGCCGAAACCGGGG36                                         (2) INFORMATION FOR SEQ ID NO:93:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:93:                                       AGGCUUGCUGAUGAGGCCGAAAGGCCGAAAACCGGG36                                         (2) INFORMATION FOR SEQ ID NO:94:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:94:                                       GAGCCUCCUGAUGAGGCCGAAAGGCCGAAAGGCUUG36                                         (2) INFORMATION FOR SEQ ID NO:95:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:95:                                       UGUCCAUCUGAUGAGGCCGAAAGGCCGAAACCAUGG36                                         (2) INFORMATION FOR SEQ ID NO:96:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:96:                                       GGGGUCCCUGAUGAGGCCGAAAGGCCGAAACUAUGC36                                         (2) INFORMATION FOR SEQ ID NO:97:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:97:                                       UGUCCAUCUGAUGAGGCCGAAAGGCCGAAACCGUGG36                                         (2) INFORMATION FOR SEQ ID NO:98:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:98:                                       GCCACAGCUGAUGAGGCCGAAAGGCCGAAAUCUGGA36                                         (2) INFORMATION FOR SEQ ID NO:99:                                              (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:99:                                       UAACAAUCUGAUGAGGCCGAAAGGCCGAAAGGGGCU36                                         (2) INFORMATION FOR SEQ ID NO:100:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:100:                                      AUAACAACUGAUGAGGCCGAAAGGCCGAAAAGGGGC36                                         (2) INFORMATION FOR SEQ ID NO:101:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:101:                                      GUAUAACCUGAUGAGGCCGAAAGGCCGAAAUAAGGG36                                         (2) INFORMATION FOR SEQ ID NO:102:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:102:                                      UGUUCAGCUGAUGAGGCCGAAAGGCCGAAAGGAGCC36                                         (2) INFORMATION FOR SEQ ID NO:103:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:103:                                      UUGUUCACUGAUGAGGCCGAAAGGCCGAAAAGGAGC36                                         (2) INFORMATION FOR SEQ ID NO:104:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:104:                                      UCGGCAGCUGAUGAGGCCGAAAGGCCGAAAGUUCUU36                                         (2) INFORMATION FOR SEQ ID NO:105:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:105:                                      GGAUCUGCUGAUGAGGCCGAAAGGCCGAAAUUUCGG36                                         (2) INFORMATION FOR SEQ ID NO:106:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:106:                                      UAACACCCUGAUGAGGCCGAAAGGCCGAAAGGGGCU36                                         (2) INFORMATION FOR SEQ ID NO:107:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:107:                                      GUUGUAUCUGAUGAGGCCGAAAGGCCGAAACACCAA36                                         (2) INFORMATION FOR SEQ ID NO:108:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:108:                                      UGCAUCUCUGAUGAGGCCGAAAGGCCGAAAGCAUCG36                                         (2) INFORMATION FOR SEQ ID NO:109:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:109:                                      AAGCCUCCUGAUGAGGCCGAAAGGCCGAAAGGCUUG36                                         (2) INFORMATION FOR SEQ ID NO:110:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:110:                                      UGUUCAACUGAUGAGGCCGAAAGGCCGAAAAAAGCC36                                         (2) INFORMATION FOR SEQ ID NO:111:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:111:                                      AUAAUGGCUGAUGAGGCCGAAAGGCCGAAAGUAGCA36                                         (2) INFORMATION FOR SEQ ID NO:112:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:112:                                      UGUCCAUCUGAUGAGGCCGAAAGGCCGAAAUGGUAG36                                         (2) INFORMATION FOR SEQ ID NO:113:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:113:                                      CUGUCCACUGAUGAGGCCGAAAGGCCGAAAAUGGUA36                                         (2) INFORMATION FOR SEQ ID NO:114:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:114:                                      GCUUGGCCUGAUGAGGCCGAAAGGCCGAAAGUUCUU36                                         (2) INFORMATION FOR SEQ ID NO:115:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:115:                                      GUCCGACCUGAUGAGGCCGAAAGGCCGAAAUGCUGG36                                         (2) INFORMATION FOR SEQ ID NO:116:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:116:                                      AAGGGCGCUGAUGAGGCCGAAAGGCCGAAAUCUCAG36                                         (2) INFORMATION FOR SEQ ID NO:117:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:117:                                      CAAGGGCCUGAUGAGGCCGAAAGGCCGAAAAUCUCA36                                         (2) INFORMATION FOR SEQ ID NO:118:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:118:                                      UAACACCCUGAUGAGGCCGAAAGGCCGAAAGGGCGA36                                         (2) INFORMATION FOR SEQ ID NO:119:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:119:                                      ACACUGGCUGAUGAGGCCGAAAGGCCGAAAUCCAUG36                                         (2) INFORMATION FOR SEQ ID NO:120:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:120:                                      GACACUUCUGAUGAGGCCGAAAGGCCGAAAUUCUGU36                                         (2) INFORMATION FOR SEQ ID NO:121:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:121:                                      UUGCAAGCUGAUGAGGCCGAAAGGCCGAAACACUUG36                                         (2) INFORMATION FOR SEQ ID NO:122:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:122:                                      GAGUUGCCUGAUGAGGCCGAAAGGCCGAAAGGACAC36                                         (2) INFORMATION FOR SEQ ID NO:123:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:123:                                      GUGCUUGCUGAUGAGGCCGAAAGGCCGAAAUCUGGG36                                         (2) INFORMATION FOR SEQ ID NO:124:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:124:                                      GAGCCUCCUGAUGAGGCCGAAAGGCCGAAAUAACUC36                                         (2) INFORMATION FOR SEQ ID NO:125:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:125:                                      GUCCUCUCUGAUGAGGCCGAAAGGCCGAAAUGCCAG36                                         (2) INFORMATION FOR SEQ ID NO:126:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:126:                                      UGGAUAACUGAUGAGGCCGAAAGGCCGAAAUUCUGU36                                         (2) INFORMATION FOR SEQ ID NO:127:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:127:                                      AUGGUAUCUGAUGAGGCCGAAAGGCCGAAACACCAA36                                         (2) INFORMATION FOR SEQ ID NO:128:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:128:                                      UCCAUGGCUGAUGAGGCCGAAAGGCCGAAAUAACAC36                                         (2) INFORMATION FOR SEQ ID NO:129:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:129:                                      ACAUUGGCUGAUGAGGCCGAAAGGCCGAAAUCCAUG36                                         (2) INFORMATION FOR SEQ ID NO:130:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:130:                                      GUCACUGCUGAUGAGGCCGAAAGGCCGAAACAUUGU36                                         (2) INFORMATION FOR SEQ ID NO:131:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:131:                                      UGUUCAGCUGAUGAGGCCGAAAGGCCGAAAACAGCC36                                         (2) INFORMATION FOR SEQ ID NO:132:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:132:                                      UUGUUCACUGAUGAGGCCGAAAGGCCGAAAAACAGC36                                         (2) INFORMATION FOR SEQ ID NO:133:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:133:                                      GGAGAAUCUGAUGAGGCCGAAAGGCCGAAAGCCUCG36                                         (2) INFORMATION FOR SEQ ID NO:134:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:134:                                      UGGUGGACUGAUGAGGCCGAAAGGCCGAAAAUGAGC36                                         (2) INFORMATION FOR SEQ ID NO:135:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:135:                                      AGUGGUGCUGAUGAGGCCGAAAGGCCGAAAGAAUGA36                                         (2) INFORMATION FOR SEQ ID NO:136:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:136:                                      CUUCCUGCUGAUGAGGCCGAAAGGCCGAAAACAGUG36                                         (2) INFORMATION FOR SEQ ID NO:137:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:137:                                      ACCGUGGCUGAUGAGGCCGAAAGGCCGAAAGUUGUG36                                         (2) INFORMATION FOR SEQ ID NO:138:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:138:                                      UGCUUGGCUGAUGAGGCCGAAAGGCCGAAACUGGGA36                                         (2) INFORMATION FOR SEQ ID NO:139:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:139:                                      CCUGUGACUGAUGAGGCCGAAAGGCCGAAAGUGGUG36                                         (2) INFORMATION FOR SEQ ID NO:140:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:140:                                      CAAGACUCUGAUGAGGCCGAAAGGCCGAAACAUGUU36                                         (2) INFORMATION FOR SEQ ID NO:141:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:141:                                      CGAUGCCCUGAUGAGGCCGAAAGGCCGAAAUGUGGU36                                         (2) INFORMATION FOR SEQ ID NO:142:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:142:                                      GAGUUGUCUGAUGAGGCCGAAAGGCCGAAAGGACAC36                                         (2) INFORMATION FOR SEQ ID NO:143:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:143:                                      GUGCUUGCUGAUGAGGCCGAAAGGCCGAAAACCGGG36                                         (2) INFORMATION FOR SEQ ID NO:144:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:144:                                      AGUGUGGCUGAUGAGGCCGAAAGGCCGAAAUCAUAG36                                         (2) INFORMATION FOR SEQ ID NO:145:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:145:                                      UUCCCAGCUGAUGAGGCCGAAAGGCCGAAAUCUGGA36                                         (2) INFORMATION FOR SEQ ID NO:146:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:146:                                      UUUCCCACUGAUGAGGCCGAAAGGCCGAAAAUCUGG36                                         (2) INFORMATION FOR SEQ ID NO:147:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:147:                                      GACACCUCUGAUGAGGCCGAAAGGCCGAAAUUCUGU36                                         (2) INFORMATION FOR SEQ ID NO:148:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:148:                                      UCUCUAGCUGAUGAGGCCGAAAGGCCGAAACACCUG36                                         (2) INFORMATION FOR SEQ ID NO:149:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:149:                                      GAGUCUCCUGAUGAGGCCGAAAGGCCGAAAGGACAC36                                         (2) INFORMATION FOR SEQ ID NO:150:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:150:                                      ACAGUGGCUGAUGAGGCCGAAAGGCCGAAAGUCUCU36                                         (2) INFORMATION FOR SEQ ID NO:151:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:151:                                      UGCUUCACUGAUGAGGCCGAAAGGCCGAAAAUGAGC36                                         (2) INFORMATION FOR SEQ ID NO:152:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:152:                                      UGGUGGACUGAUGAGGCCGAAAGGCCGAAAAUGUGC36                                         (2) INFORMATION FOR SEQ ID NO:153:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:153:                                      CAAGAUUCUGAUGAGGCCGAAAGGCCGAAACAUGUC36                                         (2) INFORMATION FOR SEQ ID NO:154:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:154:                                      AAACACCCUGAUGAGGCCGAAAGGCCGAAAGGGCCU36                                         (2) INFORMATION FOR SEQ ID NO:155:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:155:                                      UGUGUCUCUGAUGAGGCCGAAAGGCCGAAAGCAUCG36                                         (2) INFORMATION FOR SEQ ID NO:156:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:156:                                      AAAUGAACUGAUGAGGCCGAAAGGCCGAAAGGAUGC36                                         (2) INFORMATION FOR SEQ ID NO:157:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:157:                                      UCAAAUGCUGAUGAGGCCGAAAGGCCGAAAGAGGAU36                                         (2) INFORMATION FOR SEQ ID NO:158:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:158:                                      GGGAUAUCUGAUGAGGCCGAAAGGCCGAAAAGGUGC36                                         (2) INFORMATION FOR SEQ ID NO:159:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:159:                                      AACAUGACUGAUGAGGCCGAAAGGCCGAAAUUCGAG36                                         (2) INFORMATION FOR SEQ ID NO:160:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:160:                                      UGAACAUCUGAUGAGGCCGAAAGGCCGAAAGAUUCG36                                         (2) INFORMATION FOR SEQ ID NO:161:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:161:                                      UACACAACUGAUGAGGCCGAAAGGCCGAAAAUACCA36                                         (2) INFORMATION FOR SEQ ID NO:162:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:162:                                      AAAAGCUCUGAUGAGGCCGAAAGGCCGAAAUACACA36                                         (2) INFORMATION FOR SEQ ID NO:163:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:163:                                      CAAAUCACUGAUGAGGCCGAAAGGCCGAAAAUAAGU36                                         (2) INFORMATION FOR SEQ ID NO:164:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:164:                                      UCAAAUCCUGAUGAGGCCGAAAGGCCGAAAAAUAAG36                                         (2) INFORMATION FOR SEQ ID NO:165:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:165:                                      CUGCCGUCGCACCUC15                                                              (2) INFORMATION FOR SEQ ID NO:166:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:166:                                      CUGCCGUCGCACCUC15                                                              (2) INFORMATION FOR SEQ ID NO:167:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:167:                                      CUGCCGUCGCACCUC15                                                              (2) INFORMATION FOR SEQ ID NO:168:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:168:                                      CCCCGGUUCCAAGCC15                                                              (2) INFORMATION FOR SEQ ID NO:169:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:169:                                      AGAGGCUCCUUCCGA15                                                              (2) INFORMATION FOR SEQ ID NO:170:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:170:                                      GGCUCCUUCCGAACA15                                                              (2) INFORMATION FOR SEQ ID NO:171:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:171:                                      GGCUCCUUCCGAACA15                                                              (2) INFORMATION FOR SEQ ID NO:172:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:172:                                      GGCUCCUUCCGAACA15                                                              (2) INFORMATION FOR SEQ ID NO:173:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:173:                                      GGCUCCUUCCGAACA15                                                              (2) INFORMATION FOR SEQ ID NO:174:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:174:                                      GCUCCUUCCGAACAA15                                                              (2) INFORMATION FOR SEQ ID NO:175:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:175:                                      ACAGAGUUAUCGAGG15                                                              (2) INFORMATION FOR SEQ ID NO:176:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:176:                                      GAGUUAUCGAGGCAC15                                                              (2) INFORMATION FOR SEQ ID NO:177:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:177:                                      CCACACUCUCAUAGU15                                                              (2) INFORMATION FOR SEQ ID NO:178:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:178:                                      CCACACUCUCAUAGU15                                                              (2) INFORMATION FOR SEQ ID NO:179:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:179:                                      AGAGGCUCCUUCUGA15                                                              (2) INFORMATION FOR SEQ ID NO:180:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:180:                                      AGAGGCUCCUUCUGA15                                                              (2) INFORMATION FOR SEQ ID NO:181:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:181:                                      GUGUUAUACAACGGA15                                                              (2) INFORMATION FOR SEQ ID NO:182:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:182:                                      AACGGAUCCCAGUGU15                                                              (2) INFORMATION FOR SEQ ID NO:183:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:183:                                      AGAGGCUUUUCUUGA15                                                              (2) INFORMATION FOR SEQ ID NO:184:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:184:                                      AGAGGCUUUUCUUGA15                                                              (2) INFORMATION FOR SEQ ID NO:185:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:185:                                      GAGGCUUUUCUUGAA15                                                              (2) INFORMATION FOR SEQ ID NO:186:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:186:                                      AGGCUUUUCUUGAAC15                                                              (2) INFORMATION FOR SEQ ID NO:187:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:187:                                      UGCUACUACCAUUAU15                                                              (2) INFORMATION FOR SEQ ID NO:188:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:188:                                      GGCACAUACUCCACC15                                                              (2) INFORMATION FOR SEQ ID NO:189:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:189:                                      CCACUGUUACAGGAA15                                                              (2) INFORMATION FOR SEQ ID NO:190:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:190:                                      CCACUGUUACAGGAA15                                                              (2) INFORMATION FOR SEQ ID NO:191:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:191:                                      CCACUGUUACAGGAA15                                                              (2) INFORMATION FOR SEQ ID NO:192:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:192:                                      CCACUGUUACAGGAA15                                                              (2) INFORMATION FOR SEQ ID NO:193:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:193:                                      CACUGUUACAGGAAG15                                                              (2) INFORMATION FOR SEQ ID NO:194:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:194:                                      GCAUAGUCGGACCCC15                                                              (2) INFORMATION FOR SEQ ID NO:195:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:195:                                      GCAUAGUCGGACCCC15                                                              (2) INFORMATION FOR SEQ ID NO:196:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:196:                                      GCAUAGUCGGACCCC15                                                              (2) INFORMATION FOR SEQ ID NO:197:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:197:                                      AAAAACUAUCCAAAU15                                                              (2) INFORMATION FOR SEQ ID NO:198:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:198:                                      CAGGAAUCCAGAUGC15                                                              (2) INFORMATION FOR SEQ ID NO:199:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:199:                                      CAGGAAUCCAGAUGC15                                                              (2) INFORMATION FOR SEQ ID NO:200:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:200:                                      CAGGAAUCCAGAUGC15                                                              (2) INFORMATION FOR SEQ ID NO:201:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:201:                                      CAGGAAUCCAGAUGC15                                                              (2) INFORMATION FOR SEQ ID NO:202:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:202:                                      CAGGAAUCCAGAUGC15                                                              (2) INFORMATION FOR SEQ ID NO:203:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:203:                                      UCGCCCUUGGUGUUA15                                                              (2) INFORMATION FOR SEQ ID NO:204:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:204:                                      ACAAUGUCUGGUGAC15                                                              (2) INFORMATION FOR SEQ ID NO:205:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:205:                                      ACAGAAUCAAGUGUC15                                                              (2) INFORMATION FOR SEQ ID NO:206:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:206:                                      GCUUCUUCUGAAGAA15                                                              (2) INFORMATION FOR SEQ ID NO:207:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:207:                                      GACUGCUACCAUGGU15                                                              (2) INFORMATION FOR SEQ ID NO:208:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:208:                                      GAGUUAUCGAGGCUC15                                                              (2) INFORMATION FOR SEQ ID NO:209:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:209:                                      CGAGGCUCAUUCUCC15                                                              (2) INFORMATION FOR SEQ ID NO:210:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:210:                                      UCAUUCUCCACCACU15                                                              (2) INFORMATION FOR SEQ ID NO:211:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:211:                                      GACAUGUCAGUCUUG15                                                              (2) INFORMATION FOR SEQ ID NO:212:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:212:                                      UCUUGGUCCUCUAUG15                                                              (2) INFORMATION FOR SEQ ID NO:213:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:213:                                      UGGUCCUCUAUGACA15                                                              (2) INFORMATION FOR SEQ ID NO:214:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:214:                                      UGGUCCUCUAUGACA15                                                              (2) INFORMATION FOR SEQ ID NO:215:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:215:                                      GUCCUCUAUGACACC15                                                              (2) INFORMATION FOR SEQ ID NO:216:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:216:                                      AUAGAAUACUACCCA15                                                              (2) INFORMATION FOR SEQ ID NO:217:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:217:                                      AUAGAAUACUACCCA15                                                              (2) INFORMATION FOR SEQ ID NO:218:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:218:                                      AUGGAAUCAAGUGUC15                                                              (2) INFORMATION FOR SEQ ID NO:219:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:219:                                      CAAGUGUCCUUGCAA15                                                              (2) INFORMATION FOR SEQ ID NO:220:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:220:                                      UCCCAGUUCCAAGCA15                                                              (2) INFORMATION FOR SEQ ID NO:221:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:221:                                      UCGGCAUCGGAGGAU15                                                              (2) INFORMATION FOR SEQ ID NO:222:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:222:                                      UCCCAUUACGCUAUC15                                                              (2) INFORMATION FOR SEQ ID NO:223:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:223:                                      GCUCCUUCUGAACAA15                                                              (2) INFORMATION FOR SEQ ID NO:224:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:224:                                      CCAGGAUUGCUACCA15                                                              (2) INFORMATION FOR SEQ ID NO:225:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:225:                                      CCAGGAUUGCUACCA15                                                              (2) INFORMATION FOR SEQ ID NO:226:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:226:                                      GAACUGUCAGUCUUG15                                                              (2) INFORMATION FOR SEQ ID NO:227:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:227:                                      UCUUGGUCAUCUAUG15                                                              (2) INFORMATION FOR SEQ ID NO:228:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:228:                                      UGGUCAUCUAUGAUA15                                                              (2) INFORMATION FOR SEQ ID NO:229:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:229:                                      GUCAUCUAUGAUACC15                                                              (2) INFORMATION FOR SEQ ID NO:230:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:230:                                      UGGUGUUACACGACU15                                                              (2) INFORMATION FOR SEQ ID NO:231:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:231:                                      AGAGACUCCCACUGU15                                                              (2) INFORMATION FOR SEQ ID NO:232:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:232:                                      CUGUUGUUCCGGUUC15                                                              (2) INFORMATION FOR SEQ ID NO:233:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:233:                                      GCUCAUUCUGAAGCA15                                                              (2) INFORMATION FOR SEQ ID NO:234:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:234:                                      UCAAUCUUGGUCAUC15                                                              (2) INFORMATION FOR SEQ ID NO:235:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:235:                                      CCACAUUCCUGGCCC15                                                              (2) INFORMATION FOR SEQ ID NO:236:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:236:                                      GGCAAGUCAGUCUUA15                                                              (2) INFORMATION FOR SEQ ID NO:237:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:237:                                      AGGCCUUCCUUCUAC15                                                              (2) INFORMATION FOR SEQ ID NO:238:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:238:                                      AGUGUCUAGGUUGUU15                                                              (2) INFORMATION FOR SEQ ID NO:239:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:239:                                      AGUGUCUAGGUUGUU15                                                              (2) INFORMATION FOR SEQ ID NO:240:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:240:                                      UGGUAUUAUUGUGUA15                                                              (2) INFORMATION FOR SEQ ID NO:241:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 15 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:241:                                      UAAGCUUUUCCCGUC15                                                              (2) INFORMATION FOR SEQ ID NO:242:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:242:                                      GAGGUGCCUGAUGAGGCCGAAAGGCCGAAACGGCAG36                                         (2) INFORMATION FOR SEQ ID NO:243:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:243:                                      GAGGUGCCUGAUGAGGCCGAAAGGCCGAAACGGCAG36                                         (2) INFORMATION FOR SEQ ID NO:244:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:244:                                      GAGGUGCCUGAUGAGGCCGAAAGGCCGAAACGGCAG36                                         (2) INFORMATION FOR SEQ ID NO:245:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:245:                                      GGCUUGGCUGAUGAGGCCGAAAGGCCGAAACCGGGG36                                         (2) INFORMATION FOR SEQ ID NO:246:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:246:                                      UCGGAAGCUGAUGAGGCCGAAAGGCCGAAAGCCUCU36                                         (2) INFORMATION FOR SEQ ID NO:247:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:247:                                      UGUUCGGCUGAUGAGGCCGAAAGGCCGAAAGGAGCC36                                         (2) INFORMATION FOR SEQ ID NO:248:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:248:                                      UGUUCGGCUGAUGAGGCCGAAAGGCCGAAAGGAGCC36                                         (2) INFORMATION FOR SEQ ID NO:249:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:249:                                      UGUUCGGCUGAUGAGGCCGAAAGGCCGAAAGGAGCC36                                         (2) INFORMATION FOR SEQ ID NO:250:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:250:                                      UGUUCGGCUGAUGAGGCCGAAAGGCCGAAAGGAGCC36                                         (2) INFORMATION FOR SEQ ID NO:251:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:251:                                      UUGUUCGCUGAUGAGGCCGAAAGGCCGAAAAGGAGC36                                         (2) INFORMATION FOR SEQ ID NO:252:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:252:                                      CCUCGAUCUGAUGAGGCCGAAAGGCCGAAACUCUGU36                                         (2) INFORMATION FOR SEQ ID NO:253:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:253:                                      GUGCCUCCUGAUGAGGCCGAAAGGCCGAAAUAACUC36                                         (2) INFORMATION FOR SEQ ID NO:254:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:254:                                      ACUAUGACUGAUGAGGCCGAAAGGCCGAAAGUGUGG36                                         (2) INFORMATION FOR SEQ ID NO:255:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:255:                                      ACUAUGACUGAUGAGGCCGAAAGGCCGAAAGUGUGG36                                         (2) INFORMATION FOR SEQ ID NO:256:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:256:                                      UCAGAAGCUGAUGAGGCCGAAAGGCCGAAAGCCUCU36                                         (2) INFORMATION FOR SEQ ID NO:257:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:257:                                      UCAGAAGCUGAUGAGGCCGAAAGGCCGAAAGCCUCU36                                         (2) INFORMATION FOR SEQ ID NO:258:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:258:                                      UCCGUUGCUGAUGAGGCCGAAAGGCCGAAAUAACAC36                                         (2) INFORMATION FOR SEQ ID NO:259:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:259:                                      ACACUGGCUGAUGAGGCCGAAAGGCCGAAAUCCGUU36                                         (2) INFORMATION FOR SEQ ID NO:260:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:260:                                      UCAAGAACUGAUGAGGCCGAAAGGCCGAAAGCCUCU36                                         (2) INFORMATION FOR SEQ ID NO:261:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:261:                                      UCAAGAACUGAUGAGGCCGAAAGGCCGAAAGCCUCU36                                         (2) INFORMATION FOR SEQ ID NO:262:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:262:                                      UUCAAGACUGAUGAGGCCGAAAGGCCGAAAAGCCUC36                                         (2) INFORMATION FOR SEQ ID NO:263:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:263:                                      GUUCAAGCUGAUGAGGCCGAAAGGCCGAAAAAGCCU36                                         (2) INFORMATION FOR SEQ ID NO:264:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:264:                                      AUAAUGGCUGAUGAGGCCGAAAGGCCGAAAGUAGCA36                                         (2) INFORMATION FOR SEQ ID NO:265:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:265:                                      GGUGGAGCUGAUGAGGCCGAAAGGCCGAAAUGUGCC36                                         (2) INFORMATION FOR SEQ ID NO:266:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:266:                                      UUCCUGUCUGAUGAGGCCGAAAGGCCGAAACAGUGG36                                         (2) INFORMATION FOR SEQ ID NO:267:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:267:                                      UUCCUGUCUGAUGAGGCCGAAAGGCCGAAACAGUGG36                                         (2) INFORMATION FOR SEQ ID NO:268:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:268:                                      UUCCUGUCUGAUGAGGCCGAAAGGCCGAAACAGUGG36                                         (2) INFORMATION FOR SEQ ID NO:269:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:269:                                      UUCCUGUCUGAUGAGGCCGAAAGGCCGAAACAGUGG36                                         (2) INFORMATION FOR SEQ ID NO:270:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:270:                                      CUUCCUGCUGAUGAGGCCGAAAGGCCGAAAACAGUG36                                         (2) INFORMATION FOR SEQ ID NO:271:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:271:                                      GGGGUCCCUGAUGAGGCCGAAAGGCCGAAACUAUGC36                                         (2) INFORMATION FOR SEQ ID NO:272:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:272:                                      GGGGUCCCUGAUGAGGCCGAAAGGCCGAAACUAUGC36                                         (2) INFORMATION FOR SEQ ID NO:273:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:273:                                      GGGGUCCCUGAUGAGGCCGAAAGGCCGAAACUAUGC36                                         (2) INFORMATION FOR SEQ ID NO:274:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:274:                                      AUUUGGACUGAUGAGGCCGAAAGGCCGAAAGUUUUU36                                         (2) INFORMATION FOR SEQ ID NO:275:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:275:                                      GCAUCUGCUGAUGAGGCCGAAAGGCCGAAAUUCCUG36                                         (2) INFORMATION FOR SEQ ID NO:276:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:276:                                      GCAUCUGCUGAUGAGGCCGAAAGGCCGAAAUUCCUG36                                         (2) INFORMATION FOR SEQ ID NO:277:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:277:                                      GCAUCUGCUGAUGAGGCCGAAAGGCCGAAAUUCCUG36                                         (2) INFORMATION FOR SEQ ID NO:278:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:278:                                      GCAUCUGCUGAUGAGGCCGAAAGGCCGAAAUUCCUG36                                         (2) INFORMATION FOR SEQ ID NO:279:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:279:                                      GCAUCUGCUGAUGAGGCCGAAAGGCCGAAAUUCCUG36                                         (2) INFORMATION FOR SEQ ID NO:280:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:280:                                      UAACACCCUGAUGAGGCCGAAAGGCCGAAAGGGCGA36                                         (2) INFORMATION FOR SEQ ID NO:281:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:281:                                      GUCACCACUGAUGAGGCCGAAAGGCCGAAACAUUGU36                                         (2) INFORMATION FOR SEQ ID NO:282:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:282:                                      GACACUUCUGAUGAGGCCGAAAGGCCGAAAUUCUGU36                                         (2) INFORMATION FOR SEQ ID NO:283:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:283:                                      UUCUUCACUGAUGAGGCCGAAAGGCCGAAAAGAAGC36                                         (2) INFORMATION FOR SEQ ID NO:284:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:284:                                      ACCAUGGCUGAUGAGGCCGAAAGGCCGAAAGCAGUC36                                         (2) INFORMATION FOR SEQ ID NO:285:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:285:                                      GAGCCUCCUGAUGAGGCCGAAAGGCCGAAAUAACUC36                                         (2) INFORMATION FOR SEQ ID NO:286:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:286:                                      GGAGAAUCUGAUGAGGCCGAAAGGCCGAAAGCCUCG36                                         (2) INFORMATION FOR SEQ ID NO:287:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:287:                                      AGUGGUGCUGAUGAGGCCGAAAGGCCGAAAGAAUGA36                                         (2) INFORMATION FOR SEQ ID NO:288:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:288:                                      CAAGACUCUGAUGAGGCCGAAAGGCCGAAACAUGUC36                                         (2) INFORMATION FOR SEQ ID NO:289:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:289:                                      CAUAGAGCUGAUGAGGCCGAAAGGCCGAAACCAAGA36                                         (2) INFORMATION FOR SEQ ID NO:290:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:290:                                      UGUCAUACUGAUGAGGCCGAAAGGCCGAAAGGACCA36                                         (2) INFORMATION FOR SEQ ID NO:291:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:291:                                      UGUCAUACUGAUGAGGCCGAAAGGCCGAAAGGACCA36                                         (2) INFORMATION FOR SEQ ID NO:292:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:292:                                      GGUGUCACUGAUGAGGCCGAAAGGCCGAAAGAGGAC36                                         (2) INFORMATION FOR SEQ ID NO:293:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:293:                                      UGGGUAGCUGAUGAGGCCGAAAGGCCGAAAUUCUAU36                                         (2) INFORMATION FOR SEQ ID NO:294:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:294:                                      UGGGUAGCUGAUGAGGCCGAAAGGCCGAAAUUCUAU36                                         (2) INFORMATION FOR SEQ ID NO:295:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:295:                                      GACACUUCUGAUGAGGCCGAAAGGCCGAAAUUCCAU36                                         (2) INFORMATION FOR SEQ ID NO:296:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:296:                                      UUGCAAGCUGAUGAGGCCGAAAGGCCGAAACACUUG36                                         (2) INFORMATION FOR SEQ ID NO:297:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:297:                                      UGCUUGGCUGAUGAGGCCGAAAGGCCGAAACUGGGA36                                         (2) INFORMATION FOR SEQ ID NO:298:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:298:                                      AUCCUCCCUGAUGAGGCCGAAAGGCCGAAAUGCCGA36                                         (2) INFORMATION FOR SEQ ID NO:299:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:299:                                      GAUAGCGCUGAUGAGGCCGAAAGGCCGAAAAUGGGA36                                         (2) INFORMATION FOR SEQ ID NO:300:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:300:                                      UUGUUCACUGAUGAGGCCGAAAGGCCGAAAAGGAGC36                                         (2) INFORMATION FOR SEQ ID NO:301:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:301:                                      UGGUAGCCUGAUGAGGCCGAAAGGCCGAAAUCCUGG36                                         (2) INFORMATION FOR SEQ ID NO:302:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:302:                                      UGGUAGCCUGAUGAGGCCGAAAGGCCGAAAUCCUGG36                                         (2) INFORMATION FOR SEQ ID NO:303:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:303:                                      CAAGACUCUGAUGAGGCCGAAAGGCCGAAACAGUUC36                                         (2) INFORMATION FOR SEQ ID NO:304:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:304:                                      CAUAGAUCUGAUGAGGCCGAAAGGCCGAAACCAAGA36                                         (2) INFORMATION FOR SEQ ID NO:305:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:305:                                      UAUCAUACUGAUGAGGCCGAAAGGCCGAAAUGACCA36                                         (2) INFORMATION FOR SEQ ID NO:306:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:306:                                      GGUAUCACUGAUGAGGCCGAAAGGCCGAAAGAUGAC36                                         (2) INFORMATION FOR SEQ ID NO:307:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:307:                                      AGUCGUGCUGAUGAGGCCGAAAGGCCGAAAACACCA36                                         (2) INFORMATION FOR SEQ ID NO:308:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:308:                                      ACAGUGGCUGAUGAGGCCGAAAGGCCGAAAGUCUCU36                                         (2) INFORMATION FOR SEQ ID NO:309:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:309:                                      GAACCGGCUGAUGAGGCCGAAAGGCCGAAACAACAG36                                         (2) INFORMATION FOR SEQ ID NO:310:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:310:                                      UGCUUCACUGAUGAGGCCGAAAGGCCGAAAAUGAGC36                                         (2) INFORMATION FOR SEQ ID NO:311:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:311:                                      GAUGACCCUGAUGAGGCCGAAAGGCCGAAAGAUUGA36                                         (2) INFORMATION FOR SEQ ID NO:312:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:312:                                      GGGCCAGCUGAUGAGGCCGAAAGGCCGAAAAUGUGG36                                         (2) INFORMATION FOR SEQ ID NO:313:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:313:                                      UAAGACUCUGAUGAGGCCGAAAGGCCGAAACUUGCC36                                         (2) INFORMATION FOR SEQ ID NO:314:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:314:                                      GUAGAAGCUGAUGAGGCCGAAAGGCCGAAAAGGCCU36                                         (2) INFORMATION FOR SEQ ID NO:315:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:315:                                      AACAACCCUGAUGAGGCCGAAAGGCCGAAAGACACU36                                         (2) INFORMATION FOR SEQ ID NO:316:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:316:                                      AACAACCCUGAUGAGGCCGAAAGGCCGAAAGACACU36                                         (2) INFORMATION FOR SEQ ID NO:317:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:317:                                      UACACAACUGAUGAGGCCGAAAGGCCGAAAAUACCA36                                         (2) INFORMATION FOR SEQ ID NO:318:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 36 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:318:                                      GACGGGACUGAUGAGGCCGAAAGGCCGAAAAGCUUA36                                         (2) INFORMATION FOR SEQ ID NO:319:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:319:                                      GGCGCGACAGAAGUCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:320:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:320:                                      GGAGGCGCAGAAGCAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:321:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:321:                                      UUUGCUCAAGAAGUGCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:322:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:322:                                      UCUGCUCAAGAAGUGCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:323:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:323:                                      CAAUAAGGAGAAGCCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:324:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:324:                                      UGGAUUUCAGAAGUAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:325:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:325:                                      CACCAAGGAGAAGCCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:326:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:326:                                      GGGACGAAAGAAGUCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:327:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:327:                                      UUUCCUCAAGAAGUGCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:328:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:328:                                      UGUUCAGAAGAAGCCGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:329:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:329:                                      CAGUCCUGAGAAGUGGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:330:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:330:                                      ACUGGAACAGAAGUGGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:331:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:331:                                      GGCUCCUGAGAAGCCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:332:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:332:                                      AGGGUUACAGAAGUAAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:333:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:333:                                      GAGCAGCAAGAAGCACACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:334:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:334:                                      GCUCCAAGAGAAGCCUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:335:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:335:                                      ACCCUGGCAGAAGUCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:336:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:336:                                      UAGCUGGGAGAAGUGUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:337:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:337:                                      GGACUGCCGUCGCGCC16                                                             (2) INFORMATION FOR SEQ ID NO:338:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:338:                                      CUGCCGUCGCGCCUCC16                                                             (2) INFORMATION FOR SEQ ID NO:339:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:339:                                      GCACCGACUGAGCAAA16                                                             (2) INFORMATION FOR SEQ ID NO:340:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:340:                                      GCACCGACUGAGCAGA16                                                             (2) INFORMATION FOR SEQ ID NO:341:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:341:                                      UGGCAGCCCCUUAUUG16                                                             (2) INFORMATION FOR SEQ ID NO:342:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:342:                                      CUACUGCCGAAAUCCA16                                                             (2) INFORMATION FOR SEQ ID NO:343:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:343:                                      UGGCAGCCCCUUGGUG16                                                             (2) INFORMATION FOR SEQ ID NO:344:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:344:                                      GGACUGCCUUCGUCCC16                                                             (2) INFORMATION FOR SEQ ID NO:345:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:345:                                      GCACUGACUGAGGAAA16                                                             (2) INFORMATION FOR SEQ ID NO:346:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:346:                                      CGGCUGUUUCUGAACA16                                                             (2) INFORMATION FOR SEQ ID NO:347:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:347:                                      CCACAGUCCAGGACUG16                                                             (2) INFORMATION FOR SEQ ID NO:348:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:348:                                      CCACUGUUGUUCCAGU16                                                             (2) INFORMATION FOR SEQ ID NO:349:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:349:                                      GGGCUGCCCAGGAGCC16                                                             (2) INFORMATION FOR SEQ ID NO:350:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:350:                                      UUACUGCCGUAACCCU16                                                             (2) INFORMATION FOR SEQ ID NO:351:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:351:                                      GUGCUGACUGCUGCUC16                                                             (2) INFORMATION FOR SEQ ID NO:352:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:352:                                      AGGCUGUUCUUGGAGC16                                                             (2) INFORMATION FOR SEQ ID NO:353:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:353:                                      UGACAGUUGCCAGGGU16                                                             (2) INFORMATION FOR SEQ ID NO:354:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:354:                                      ACACUGUUCCCAGCUA16                                                             (2) INFORMATION FOR SEQ ID NO:355:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:355:                                      GGUGCGACAGAAGUCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:356:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:356:                                      GGAGGUGCAGAAGCAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:357:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:357:                                      UUUGCUCAAGAAGUGCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:358:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:358:                                      CAAUAAGGAGAAGCCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:359:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:359:                                      CAAUAAGGAGAAGCCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:360:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:360:                                      GGAGGUGCAGAAGCAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:361:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:361:                                      UUUGCUCAAGAAGUGCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:362:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:362:                                      CAAUAAGGAGAAGCCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:363:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:363:                                      GGUGCGACAGAAGUCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:364:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:364:                                      GGAGGUGCAGAAGCAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:365:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:365:                                      UGGAUUUCAGAAGUAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:366:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:366:                                      CACCAAGGAGAAGCCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:367:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:367:                                      UGUUCAGAAGAAGCCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:368:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:368:                                      GACCCCAGAGAAGUUUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:369:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:369:                                      ACCGGAACAGAAGUGGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:370:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:370:                                      AAGCAGCAAGAAGCACACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:371:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:371:                                      AAUUUGGAAGAAGCAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:372:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:372:                                      UCAGUCCAAGAAGUGAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:373:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 52 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:373:                                      UAGCUGGGAGAAGUGUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA52                         (2) INFORMATION FOR SEQ ID NO:374:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:374:                                      GGACUGCCGUCGCACC16                                                             (2) INFORMATION FOR SEQ ID NO:375:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:375:                                      CUGCCGUCGCACCUCC16                                                             (2) INFORMATION FOR SEQ ID NO:376:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:376:                                      GCACCGACUGAGCAAA16                                                             (2) INFORMATION FOR SEQ ID NO:377:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:377:                                      UGGCAGCCCCUUAUUG16                                                             (2) INFORMATION FOR SEQ ID NO:378:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:378:                                      UGGCAGCCCCUUAUUG16                                                             (2) INFORMATION FOR SEQ ID NO:379:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:379:                                      CUGCAGUCGCACCUCC16                                                             (2) INFORMATION FOR SEQ ID NO:380:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:380:                                      GCACCGACUGAGCAAA16                                                             (2) INFORMATION FOR SEQ ID NO:381:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:381:                                      UGGCAGCCCCUUAUUG16                                                             (2) INFORMATION FOR SEQ ID NO:382:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:382:                                      GGACUGCCGUCGCACC16                                                             (2) INFORMATION FOR SEQ ID NO:383:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:383:                                      CUGCCGUCGCACCUCC16                                                             (2) INFORMATION FOR SEQ ID NO:384:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:384:                                      CUACUGCCGAAAUCCA16                                                             (2) INFORMATION FOR SEQ ID NO:385:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:385:                                      UGGCAGCCCCUUGGUG16                                                             (2) INFORMATION FOR SEQ ID NO:386:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:386:                                      UGGCUGUUUCUGAACA16                                                             (2) INFORMATION FOR SEQ ID NO:387:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:387:                                      AAACAGCCCUGGGGUC16                                                             (2) INFORMATION FOR SEQ ID NO:388:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:388:                                      CCACUGUUGUUCCGGU16                                                             (2) INFORMATION FOR SEQ ID NO:389:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:389:                                      GUGCUGACUGCUGCUU16                                                             (2) INFORMATION FOR SEQ ID NO:390:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:390:                                      CUGCCGUCUCCAAAUU16                                                             (2) INFORMATION FOR SEQ ID NO:391:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:391:                                      UCACCGCCUGGACUGA16                                                             (2) INFORMATION FOR SEQ ID NO:392:                                             (i) SEQUENCE CHARACTERISTICS:                                                  (A) LENGTH: 16 base pairs                                                      (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                           (xi) SEQUENCE DESCRIPTION: SEQ ID NO:392:                                      ACACUGUCCCCAGCUA16                                                             __________________________________________________________________________ 

We claim:
 1. An enzymatic RNA molecule which specifically cleaves apo(a) mRNA.
 2. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule is in a hammerhead motif.
 3. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves any one of the sequences defined as SEQ. ID. NOS. 7-85.
 4. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule is in a hairpin, hepatitis delta virus, group I intron, Neurospora VS RNA or RNaseP RNA motif.
 5. The enzymatic RNA molecule of claim 4, wherein said hairpin specifically cleaves any of the sequences defined as SEQ. ID. NOs. 165-241, 337-354, or 374-392.
 6. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule comprises between 12 and 100 bases complementary to said mRNA.
 7. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule comprises between 14 and 24 bases complementary to said mRNA.
 8. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule comprises any of sequences shown as SEQ. ID. Nos. 86-164, or 242-318.
 9. The enzymatic RNA molecule of claim 4, wherein said hairpin comprises any of the sequences shown as SEQ. ID. NOs. 319-336, or 355-373.
 10. The enzymatic RNA molecule of claim 2, wherein said hammerhead comprises a stem II region, and wherein said stem II is greater than or equal to 2 base pairs long.
 11. The enzymatic RNA molecule of claim 4, wherein said hairpin comprises a stem IV region, and wherein said stem IV is greater than or equal to 2 base pairs long.
 12. The enzymatic RNA molecule of any of claims 1, 3, 5, 2, 4, 6-8 and 9-11, wherein said enzymatic RNA molecule comprises at least one sugar modification.
 13. The enzymatic RNA molecule of any of claims 1, 3, 5, 2, 4, 6-8 and 9-11, wherein said enzymatic RNA molecule comprises at least one base modification.
 14. The enzymatic RNA molecule of any of claims 1, 3, 5, 2, 4, 6-8 and 9-11, wherein said nucleic acid comprises at least one phosphate modification.
 15. The enzymatic RNA molecule of any of claims 1, 3, 5, 2, 4, 6-8 and 9-11, wherein said enzymatic RNA molecule comprises at least two sugar modifications, wherein one said modification is a 2'-O-methyl and the other said modification is a 2'-deoxy-2'-amino.
 16. The enzymatic RNA molecule of any of claims 1, 3, 5, 2, 4, 6-8 and 9-11, wherein said enzymatic RNA molecule comprises at least two sugar modifications, wherein one said modification is a 2'-O-methyl and the other said modification is a 2'-C-allyl.
 17. The enzymatic RNA molecule of claim 14, wherein said phosphate modification is a phosphorothioate.
 18. A mammalian cell including an enzymatic nucleic acid molecule of any of claims 1, 3, 5, 2, 4, 6-8 in vitro.
 19. The cell of claim 18, wherein said cell is a human cell.
 20. An expression vector including a nucleic acid encoding an enzymatic RNA molecule or multiple enzymatic RNA molecules of claims 1, 3, 5, 2, 4, 6-8 in a manner which allows expression of that enzymatic RNA molecule(s) within a mammalian cell in vitro.
 21. A mammalian cell in vitro including the expression vector of claim
 20. 22. The cell of claim 12, wherein said cell is a human cell. 